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Complete Absence of CD3γ Protein Expression Is Responsible for Combined Immunodeficiency with Autoimmunity Rather than SCID

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Acknowledgments

We thank the patient and his parents, and healthy volunteers, for participating in this work.

Funding

This study was supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, and the Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH.

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Authors and Affiliations

  1. Laboratory of Clinical Immunology and Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

    Ottavia M. Delmonte, Adam K. Dobbs & Luigi D. Notarangelo

  2. Division of Hematology-Oncology, Boston Children’s Hospital, Boston, MA, USA

    Jared H. Rowe

  3. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Boaz Palterer

  4. Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy

    Riccardo Castagnoli

Authors
  1. Ottavia M. Delmonte
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  2. Jared H. Rowe
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  3. Adam K. Dobbs
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  4. Boaz Palterer
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  5. Riccardo Castagnoli
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  6. Luigi D. Notarangelo
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Contributions

O.M.D., J.H.R., L.D.N. conceived the study and designed the experiments. J.H.R., O.M.D., R.C. and L.D.N. analyzed the data and drafted the manuscript. O.M.D., J.H.R. provided clinical care. O.M.D., J.H.R., A.K.D., B.P. performed the experiments and analyzed the data. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ottavia M. Delmonte.

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The authors declare that they have no conflict of interest.

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Delmonte, O.M., Rowe, J.H., Dobbs, A.K. et al. Complete Absence of CD3γ Protein Expression Is Responsible for Combined Immunodeficiency with Autoimmunity Rather than SCID. J Clin Immunol 41, 482–485 (2021). https://doi.org/10.1007/s10875-020-00918-z

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  • DOI: https://doi.org/10.1007/s10875-020-00918-z

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