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DNA Ligase IV Deficiency Identified by Chance Following Vaccine-Derived Rubella Virus Infection

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Fig. 1

Abbreviations

ALT:

Alanine aminotransferase

AST:

Aspartate aminotransferase

BMT :

Bone marrow transplantation

CDR3:

Complementarity-determining region 3

GVHD:

Graft-versus-host disease

HSCT:

Hematopoietic stem cell transplantation

iVDRV:

Immunodeficiency-related vaccine-derived rubella virus

PID:

Primary immunodeficiency disease

KRECs:

Kappa-deleting recombination excision circles

PBMCs:

Peripheral blood mononuclear cells

SCID:

Severe combined immunodeficiency

TRECs:

T cell receptor excision circles

VDRV:

Vaccine-derived rubella virus

VZV:

Varicella-zoster virus

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Acknowledgments

We thank Drs. Harutaka Katano and Hideki Hasegawa at the Department of Pathology, National Institute of Infectious Diseases, for performing the immunohistochemical staining of rubella antigen, and Drs. Tzu-Wen Yeh and Kay Tanita for their technical assistance. We also thank Enago (www.enago.jp) for the English language review.

Funding

This work was supported by the MEXT/JSPS KAKENHI (Grant Number: JP17K10099) to HK.

Author information

Authors and Affiliations

  1. Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Kazuaki Matsumoto, Akihiro Hoshino, Akira Nishimura, Noriko Mitsuiki, Masatoshi Takagi & Tomohiro Morio

  2. Department of Pediatrics, National Defense Medical College, Tokorozawa, Japan

    Tamaki Kato & Shigeaki Nonoyama

  3. Department of Virology III, National Institute of Infectious Diseases, Tokyo, Japan

    Yoshio Mori

  4. Department of Allergy and Clinical Immunology, Shizuoka Children’s Hospital, Shizuoka, Japan

    Masaki Shimomura & Chie Naito

  5. Department of Hematology and Oncology, Shizuoka Children’s Hospital, Shizuoka, Japan

    Kenichiro Watanabe

  6. Department of Pathology, Shizuoka Children’s Hospital, Shizuoka, Japan

    Minoru Hamazaki

  7. Department of Community Pediatrics, Perinatal and Maternal Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Kohsuke Imai

  8. Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    Hirokazu Kanegane

Authors
  1. Kazuaki Matsumoto
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  2. Akihiro Hoshino
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  3. Akira Nishimura
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  4. Tamaki Kato
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  5. Yoshio Mori
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  6. Masaki Shimomura
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  7. Chie Naito
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  8. Kenichiro Watanabe
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  9. Minoru Hamazaki
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  10. Noriko Mitsuiki
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  11. Masatoshi Takagi
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  12. Kohsuke Imai
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  13. Shigeaki Nonoyama
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  14. Hirokazu Kanegane
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  15. Tomohiro Morio
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Contributions

KM contributed to data collection and writing of the manuscript. AH and TK performed the genetic analysis. YM performed the virological study. MH contributed to the pathological diagnosis. KM, AH, AN, MS, CN, KW, NM, MT, and KI treated the patient. SN and TM supervised the study. HK conceptualized the study and extensively edited and revised the manuscript.

Corresponding author

Correspondence to Hirokazu Kanegane.

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The authors declare that they have no conflict of interest.

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Matsumoto, K., Hoshino, A., Nishimura, A. et al. DNA Ligase IV Deficiency Identified by Chance Following Vaccine-Derived Rubella Virus Infection. J Clin Immunol 40, 1187–1190 (2020). https://doi.org/10.1007/s10875-020-00831-5

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  • DOI: https://doi.org/10.1007/s10875-020-00831-5

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