Abstract
Chronic wounds are a rare complication of X-linked agammaglobulinaemia (XLA). Fastidious organisms such as helicobacter bills have been reported in XLA with chronic wounds but sterile chronic wounds also occur. Hyperbaric Oxygen Therapy has been used in chronic wounds but has not previously been reported in primary antibody deficiencies. We present a case of a chronic wound in a patient with XLA refractory to antimicrobial therapy that made a remarkable recovery following Hyperbaric Oxygen Therapy.
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Murray PR, Jain A, Uzel G, Ranken R, Ivy C, Blyn LB, et al. Pyoderma gangrenosum-like ulcer in a patient with X-linked agammaglobulinemia: identification of Helicobacter bilis by mass spectrometry analysis. Arch Dermatol. 2010;146(5):523–6.
Dua J, Elliot E, Bright P, Grigoriadou S, Bull R, Millar M, et al. Pyoderma gangrenosum-like ulcer caused by Helicobacter cinaedi in a patient with x-linked agammaglobulinaemia. Clin Exp Dermatol. 2012;37(6):642–5.
Weir S, Cuccherini B, Whitney AM, Ray ML, MacGregor JP, Steigerwalt A, et al. Recurrent bacteremia caused by a “Flexispira”-like organism in a patient with X-linked (Bruton’s) agammaglobulinemia. J Clin Microbiol. 1999;37(8):2439–45.
Schwartzfarb EM, Weir D, Conlan WA, Romanelli P, Kirsner RS. Pyoderma gangrenosum in a patient with Bruton’s X-linked agammaglobulinemia: shared pathogenesis of altered tumor necrosis factor alpha? J Clin Aesthet Dermatol. 2008;1(1):26–9.
Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, Hunt TK, et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 2009;17(6):763–71.
Thackham JA, McElwain DL, Long RJ. The use of hyperbaric oxygen therapy to treat chronic wounds: a review. Wound Repair Regen. 2008;16(3):321–30.
Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy (1985). J Appl Physiol. 2009;106(3):988–95.
Kranke P, Bennett MH, Martyn-St James M, Schnabel A, Debus SE. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev. 2012;4:CD004123.
Beltz K, Christaras A, Kovacevic A, Schaper J, Strelow H, Niehues T. A novel element in the management of chronic granulomatous disease (CGD)? - treatment of osteomyelitis with additional hyperbaric oxygen therapy (HBO). Klin Padiatr. 2008;220(6):380–3.
Li J, Chen J, Kirsner R. Pathophysiology of acute wound healing. Clin Dermatol. 2007;25(1):9–18.
Nusbaum AG, Kirsner RS, Charles CA. Biofilms in dermatology. Skin Ther Lett. 2012;17(7):1–5.
Al-Waili NS, Butler GJ. Effects of hyperbaric oxygen on inflammatory response to wound and trauma: possible mechanism of action. Sci World J. 2006;6:425–41.
Acknowledgements
The authors wish to thanks Dr. M. Walsh, Consultant Histopathologist, Belfast H&SC Trust and Dr. M. Wilks, Clinical Scientist, the Royal London Hospital for their assistance in the examination of the pathological specimens.
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Steele, C.L., Cridge, C. & Edgar, J.D.M. A Novel Treatment in X-Linked Agammaglobulinaemia - Hyperbaric Oxygen Therapy in Refractory Chronic Wounds. J Clin Immunol 34, 784–787 (2014). https://doi.org/10.1007/s10875-014-0078-4
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DOI: https://doi.org/10.1007/s10875-014-0078-4