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The Role of IgA and IgA Fc Receptors as Anti-Inflammatory Agents

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Abstract

Materials and methods

Serum monomeric immunoglobulin A (IgA) has powerful immunomodulatory roles in its ability to suppress immune responses. Monomeric IgA acts through FcαRI, which plays a significant role in vivo in maintaining the integrity of immune responses by an inhibitory immunoreceptor tyrosine-based activation motif-mediated process and powerful inhibitory cellular effector mechanisms elicited by the IgA system.

Results

Triggering of FcαRI-mediated inhibitory function by Fab anti-FcαRI-mediated inhibitory function is able to inhibit several inflammatory and autoimmune diseases including asthma and glomerulonephritis.

Conclusion

The use of monomeric IgA as a therapeutic tool in human inflammatory diseases may offer much potential.

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Authors and Affiliations

  1. Inserm U699, Paris, France

    Renato C. Monteiro

  2. Bichat Medical School, Paris Diderot University, 16 rue Henri Huchard, 75018, Paris Cedex, France

    Renato C. Monteiro

Authors
  1. Renato C. Monteiro
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Corresponding author

Correspondence to Renato C. Monteiro.

Additional information

A longer version of this article appeared online in the Journal of Clinical Immunology: Monteiro RC: Role of IgA and IgA Fc receptors in inflammation (published online ahead of print, October 16, 2009).

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Monteiro, R.C. The Role of IgA and IgA Fc Receptors as Anti-Inflammatory Agents. J Clin Immunol 30 (Suppl 1), 61–64 (2010). https://doi.org/10.1007/s10875-010-9397-2

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  • DOI: https://doi.org/10.1007/s10875-010-9397-2

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