Abstract
The Q cycle mechanism proposed by Peter Mitchell in the 1970’s explicitly considered the modification of ubiquinone two-electron redox properties upon binding to Complex III to match the thermodynamics of the other single-electron redox cofactors in the complex, and guide electron transfer to support the generation of a proton electro-chemical gradient across native membranes. A better understanding of the engineering of Complex III is coming from a now moderately well defined thermodynamic description of the redox components as a function of pH, including the Qi/heme b H cluster. The redox properties of the most obscure component, Qo, is finally beginning to be resolved.
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Invited paper, special “Peter Mitchell 30th anniversary” issue of Journal of Bioenergetics and Biomembranes
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Zhang, H., Chobot, S.E., Osyczka, A. et al. Quinone and non-quinone redox couples in Complex III. J Bioenerg Biomembr 40, 493–499 (2008). https://doi.org/10.1007/s10863-008-9174-6
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DOI: https://doi.org/10.1007/s10863-008-9174-6