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Evaluation of various silver-containing dressing on infected excision wound healing study

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Abstract

Silver-containing dressings have been widely used for controlling wound infection. However, the relationship between different concentrations of silver in dressings and their antimicrobial activities and wound-healing efficacies remains unclear. In the present study, we (in cooperation with Bio-medical Carbon Technology) investigated various silver-containing activated carbon fibers to understand the effects of different silver concentrations on the efficacies of a silver containing dressing. Our results indicated that various silver-containing activated carbon fibers exhibited good antibacterial effects and biocompatibility in terms of cell viability and that silver concentration showed a minor influence on cell growth. The infected excision wound model indicated that compared to silver-containing activated carbon fiber and other commercial silver-containing dressings assisted wound healing by promoting granulation and collagen deposition. Meanwhile, the silver ion can only be restrained in epidermis by intact skin. During application on the wound area, a temporary increase of serum silver can be detected, but this elevated serum silver level decreased to a subtle level after the removal of silver-containing activated carbon fiber.

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Authors and Affiliations

  1. Department of Biological Science and Technology, China Medical University, Taichung, Taiwan

    Yu-Hsin Lin

  2. Bio-medical Carbon Technology Co., Ltd., Taichung, Taiwan

    Wei-Shan Hsu, Wan-Yu Chung & Jui-Hsiang Lin

  3. Department of Materials Science and Engineering, Feng Chia University, Taichung, Taiwan

    Tse-Hao Ko

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  1. Yu-Hsin Lin
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  2. Wei-Shan Hsu
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  3. Wan-Yu Chung
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  4. Tse-Hao Ko
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  5. Jui-Hsiang Lin
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Correspondence to Yu-Hsin Lin or Jui-Hsiang Lin.

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Jui-Hsiang Lin and Yu-Hsin Lin are contributed equally.

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Lin, YH., Hsu, WS., Chung, WY. et al. Evaluation of various silver-containing dressing on infected excision wound healing study. J Mater Sci: Mater Med 25, 1375–1386 (2014). https://doi.org/10.1007/s10856-014-5152-1

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  • DOI: https://doi.org/10.1007/s10856-014-5152-1

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