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Preparation and characterization of temperature-responsive magnetic composite particles for multi-modal cancer therapy

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Abstract

The temperature-responsive magnetic composite particles were synthesized by emulsion-free polymerization of N-isopropylacrylamide (NIPAAm) and acrylamide (Am) in the presence of oleic acid-modified Fe3O4 nanoparticles. The magnetic properties and heat generation ability of the composite particles were characterized. Furthermore, temperature and alternating magnetic field (AMF) triggered drug release behaviors of vitamin B12-loaded composite particles were also examined. It was found that composite particles enabled drug release to be controlled through temperature changes in the neighborhood of lower critical solution temperature. Continuous application of AMF resulted in an accelerated release of the loaded drug. On the other hand, intermittent AMF application to the composite particles resulted in an “on–off”, stepwise release pattern. Longer release duration and larger overall release could be achieved by intermittent application of AMF as compared to continuous magnetic field. Such composite particles may be used for magnetic drug targeting followed by simultaneous hyperthermia and drug release.

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Acknowledgments

This work was financially supported by National Natural Science Foundation of China (No. 50702037) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Tongji University, Shanghai, 200092, China

    Aihua Yao, Qi Chen, Fanrong Ai, Deping Wang & Wenhai Huang

  2. Key Laboratory of Advanced Civil Engineering Materials, Ministry of Education, Tongji University, Shanghai, 200092, China

    Aihua Yao, Deping Wang & Wenhai Huang

  3. College of Mechanical and Electrical Engineering, Nanchang University, Nanchang Jiangxi, 330031, China

    Fanrong Ai

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  1. Aihua Yao
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  2. Qi Chen
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  3. Fanrong Ai
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  4. Deping Wang
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  5. Wenhai Huang
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Correspondence to Aihua Yao.

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Yao, A., Chen, Q., Ai, F. et al. Preparation and characterization of temperature-responsive magnetic composite particles for multi-modal cancer therapy. J Mater Sci: Mater Med 22, 2239 (2011). https://doi.org/10.1007/s10856-011-4413-5

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  • DOI: https://doi.org/10.1007/s10856-011-4413-5

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