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Tuning anti-microbial activity of poly(4-vinyl 2-hydroxyethyl pyridinium) chloride by anion exchange reactions

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Abstract

A series of new bioactive polymers with pendant choline analogous group was prepared by anion exchange reaction direct at the quaternary nitrogen of the polycation. Poly(4-vinyl 2-hydroxyethyl pyridinium) chloride was prepared in situ by simultaneous polymerization and quaternization of 4-vinyl pyridine with 2-chloroethanol that also acts as catalyst. The counter anion (Cl−) of the polycation was exchanged by anion exchange reaction with Br−, −OH, −SH, NO3 −, BF4 − or CF3COO−. Evidence of anion exchange was obtained by the characterization of the resultant polymers. The nature of the counter anion has profound effect on their properties including strong anion-dependent anti-microbial activity against bacteria and fungus. Polymer containing −OH was observed to be the most potent anti-microbial agent with the lowest minimum inhibitory concentration against both the classes of microbes studied.

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Authors and Affiliations

  1. Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India

    Sunil K. Sharma & Ghanshyam S. Chauhan

  2. Department of Biotechnology, Himachal Pradesh University, Shimla, 171005, India

    Reena Gupta

  3. Department of Chemical and Biological Engineering and Engineering Research Institute, Gyeongsang National University, Jinju, 660 701, Republic of Korea

    J.-H. Ahn

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  1. Sunil K. Sharma
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  2. Ghanshyam S. Chauhan
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  3. Reena Gupta
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  4. J.-H. Ahn
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Correspondence to Ghanshyam S. Chauhan.

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Sharma, S.K., Chauhan, G.S., Gupta, R. et al. Tuning anti-microbial activity of poly(4-vinyl 2-hydroxyethyl pyridinium) chloride by anion exchange reactions. J Mater Sci: Mater Med 21, 717–724 (2010). https://doi.org/10.1007/s10856-009-3932-9

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  • DOI: https://doi.org/10.1007/s10856-009-3932-9

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