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Hybrid structure in PCL-HAp scaffold resulting from biomimetic apatite growth

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Abstract

Polymer–ceramic composites are favourite candidates when aiming to replace bone tissue. We present here scaffolds made of polycaprolactone-hydroxyapatite (PCL-HAp) composites, and investigate in vitro mineralisation of the scaffolds in SBF after or without a nucleation treatment. In vitro bioactivity is enhanced by HAp incorporation as well as by nucleation treatment, as demonstrated by simulated body fluid (SBF) mineralization. Surprisingly, we obtained a hybrid interconnected organic-inorganic structure, as a result of micropore invasion by biomimetic apatite, which results in a mechanical strengthening of the material after two weeks of immersion in SBF×2. The presented scaffolds, due to their multiple qualities, are expected to be valuable supports for bone tissue engineering.

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Acknowledgements

The support of the Spanish Ministry of Science through projects no. MAT2007-66759-C03-01 and MAT2007-66759-C03-02 (including the FEDER financial support), and Consellería Valenciana de Sanidad through project AP-111/08 is acknowledged. The authors acknowledge Dr. Mayelin Guerra for kindly providing them with hydroxyapatite nanoparticles for this study. SEM was performed under the technical guide of the Microscopy Service at the Universidad Politécnica de Valencia.

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Authors and Affiliations

  1. CIBER en Bioingeniería, Biomateriales y Nanomedicina, Valencia, Spain

    M. Lebourg, J. Suay Antón & J. L. Gomez Ribelles

  2. Center for Biomaterials and Tissue Engineering, Universidad Politécnica de Valencia, 46022, Valencia, Spain

    J. Suay Antón & J. L. Gomez Ribelles

  3. Regenerative Medicine Unit, Centro de Investigación Príncipe Felipe, Autopista del Saler 16, 46013, Valencia, Spain

    J. Suay Antón & J. L. Gomez Ribelles

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  1. M. Lebourg
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  2. J. Suay Antón
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  3. J. L. Gomez Ribelles
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Correspondence to M. Lebourg.

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Lebourg, M., Antón, J.S. & Ribelles, J.L.G. Hybrid structure in PCL-HAp scaffold resulting from biomimetic apatite growth. J Mater Sci: Mater Med 21, 33–44 (2010). https://doi.org/10.1007/s10856-009-3838-6

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  • DOI: https://doi.org/10.1007/s10856-009-3838-6

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