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Preparation and mechanical properties of carbon fiber reinforced hydroxyapatite/polylactide biocomposites

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Abstract

A novel biocomposite of carbon fiber (CF) reinforced hydroxyapatite (HA)/polylactide (PLA) was prepared by hot pressing a prepreg which consisting of PLA, HA and CF. The prepreg was manufactured by solvent impregnation process. Polymer resin PLA dissolved with chloroform was mixed with HA. After reinforcement CF bundle was impregnated in the mixture, the solvent was dried completely and subsequently hot-pressed uniaxially under a pressure of 40 MPa at 170°C for 20 min. A study was carried out to investigate change in mechanical properties of CF/HA/PLA composites before and after degradation in vitro. The composites have excellent mechanical properties. A peak showed in flexural strength, flexural modulus and shear strength aspects, reaching up 430 MPa, 22 GPa, 212 MPa, respectively, as the HA content increased. Degraded in vitro for 3 months, the flexural strength and flexural modulus of the CF/HA/PLA fell 13.2% and 5.4%, respectively, while the shear strength of the CF/HA/PLA composites remains at the 190 MPa level. The SEM photos showed that there were gaps between the PLA matrix and CF after degradation. Water uptake increased to 5%, but the mass loss rate was only 1.6%. The pH values of the PBS dropped less than 0.1. That’s because the alkaline of HA neutralize the acid degrades from PLA, which can prevent the body from the acidity harm.

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References

  1. Anderson LD. Treatment of ununited fractures of the long bones; compression plate fixation and the effect of different types of internal fixation on fracture healing. J Bone Joint Surg Am A. 1965;47:191.

    CAS  Google Scholar 

  2. Terjesen T. Bone healing after metal plate fixation and external fixation of the osteotomized rabbit tibia. Acta Orthop Scand. 1984;55:69.

    Article  CAS  PubMed  Google Scholar 

  3. Terjesen T, Apalset K. The influence of different degrees of stiffness of fixation plates on experimental bone healing. J Orthop Res. 1988;6:293. doi:10.1002/jor.1100060218.

    Article  CAS  PubMed  Google Scholar 

  4. Uchikura C, Hirano J, Kudo F, Satomi K, Ohno T. Comparative study of nonbridging and bridging external fixators for unstable distal radius fractures. J Orthop Sci. 2004;9:560. doi:10.1007/s00776-004-0828-x.

    Article  PubMed  Google Scholar 

  5. Huang TL, Huang CK, Yu JK, Chiu FY, Liu HT, Liu CL, et al. Operative treatment of intra-articular distal radius fractures using the small AO external fixation device. J Chin Med Assoc. 2005;68:474.

    Article  PubMed  Google Scholar 

  6. Luklinska ZB, Bonfield W. Morphology and ultrastructure of the interface between hydroxyapatite-polyhydroxybutyrate composite implant and bone. J Mater Sci: Mater Med. 1997;8:379. doi:10.1023/A:1018589018205.

    Article  CAS  Google Scholar 

  7. Rho JY, Kuhn-Spearing L, Zioupos P. Mechanical properties and the hierarchical structure of bone. Med Eng Phys. 1998;20:92. doi:10.1016/S1350-4533(98)00007-1.

    Article  CAS  PubMed  Google Scholar 

  8. Yasunaga T, Matsusue Y, Furukawa T, Shikinami Y, Okuno M, Nakamura T. Bonding behavior of ultrahigh strength unsintered hydroxyapatite particles/poly(l-lactide) composites to surface of tibial cortex in rabbits. J Biomed Mater Res. 1999;47:412. doi:10.1002/(SICI)1097-4636(19991205)47:3<412::AID-JBM17>3.0.CO;2-B.

    Article  CAS  PubMed  Google Scholar 

  9. Kulkarni RK, Moore EG, Hegyeli AF, Leonard F. Biodegradable poly(lactic acid) polymers. J Biomed Mater Res. 1971;5:169. doi:10.1002/jbm.820050305.

    Article  CAS  PubMed  Google Scholar 

  10. Vainionpää S, Rokkanen P, Törmälä P. Surgical applications of biodegradable polymers in human tissues. Prog Polym Sci. 1989;14:679. doi:10.1016/0079-6700(89)90013-0.

    Article  Google Scholar 

  11. Matsusue Y, Yamamuro T, Ikada Y. Tissue reaction of bioabsorbable ultra high strength poly (l-lactide) rod. A long-term study in rabbits. Clin Orthop Relat Res. 1995;317:246.

    PubMed  Google Scholar 

  12. Devin JE, Attawia MA, Laurencin CT. Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. J Biomater Sci Polym Ed. 1996;7:661. doi:10.1163/156856296X00435.

    Article  CAS  PubMed  Google Scholar 

  13. Marra KG, Szem JW, Kumta PN, DiMilla PA, Weiss LE. In vitro analysis of biodegradable polymer blend/hydroxyapatite composites for bone tissue engineering. J Biomed Mater Res. 1999;47:324. doi:10.1002/(SICI)1097-4636(19991205)47:3<324::AID-JBM6>3.0.CO;2-Y.

    Article  CAS  PubMed  Google Scholar 

  14. Bleach NC, Tanner KE. Effect of filler type on the mechanical properties of self-reinforced polylactide-calcium phosphate composites. J Mater Sci: Mater Med. 2001;12:911. doi:10.1023/A:1012884310027.

    Article  CAS  Google Scholar 

  15. Maquet V, Boccaccini AR, Pravata L, Notingher I, Jérôme R. Porous poly(alpha-hydroxyacid)/Bioglass composite scaffolds for bone tissue engineering. I: Preparation and in vitro characterisation. Biomaterials. 2004;25:4185. doi:10.1016/j.biomaterials.2003.10.082.

    Article  CAS  PubMed  Google Scholar 

  16. Zhang R, Ma PX. Poly(alpha-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. J Biomed Mater Res. 1999;44:446. doi:10.1002/(SICI)1097-4636(19990315)44:4<446::AID-JBM11>3.0.CO;2-F.

    Article  CAS  PubMed  MathSciNet  Google Scholar 

  17. Shikinami Y, Okuno M. Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly l-lactide (PLLA). Part II: practical properties of miniscrews and miniplates. Biomaterials. 2001;22:3197. doi:10.1016/S0142-9612(01)00072-2.

    Article  CAS  PubMed  Google Scholar 

  18. Kasuga T, Maeda TH, Kato K. Preparation of poly(lactic acid) composites containing calcium carbonate (vaterite). Biomaterials. 2003;24:3247. doi:10.1016/S0142-9612(03)00190-X.

    Article  CAS  PubMed  Google Scholar 

  19. Hong ZK, Zhang PB, He CL. Nano-composite of poly(l-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility. Biomaterials. 2005;26:6296. doi:10.1016/j.biomaterials.2005.04.018.

    Article  CAS  PubMed  Google Scholar 

  20. Chlopek J, Morawska-Chochol A, Bajor G, Adwent M, Cieslik-Bielecka A, Cieslik M, et al. The influence of carbon fibres on the resorption time and mechanical properties of the lactide-glycolide co-polymer. J Biomater Sci Polym Ed. 2007;18:1355. doi:10.1163/156856207782246858.

    Article  CAS  PubMed  Google Scholar 

  21. Hojo Y, Kotani Y, Ito M, Abumi K, Kadosawa T, Shikinami Y, et al. A biomechanical and histological evaluation of a bioresorbable lumbar interbody fusion cage. Biomaterials. 2005;26:2643. doi:10.1016/j.biomaterials.2004.07.020.

    Article  CAS  PubMed  Google Scholar 

  22. Al-Shawi AK, Smith SP, Anderson GH. The use of a carbon fiber plate for periprosthetic supracondylar femoral fractures. J Arthroplasty. 2002;17:320. doi:10.1054/arth.2002.30291.

    Article  CAS  PubMed  Google Scholar 

  23. Czajkowska B, Bhiewicz M. Phagocytosis of chemically modified carbon materials. Biomaterials. 1997;18:69. doi:10.1016/S0142-9612(96)00103-2.

    Article  CAS  PubMed  Google Scholar 

  24. BS 2782: Part 3: Methods 340A and 340B. London: British Standards Institution; 1978.

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Acknowledgment

This work is financed by the Science & Technology Department of Zhejiang Province of China (Grant no. 2005C21049).

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Authors and Affiliations

  1. Department of Polymer Science and Engineering, Key Laboratory of Macromolecular Synthesis and Functionalization, Ministry of Education, Zhejiang University, Hangzhou, 310027, China

    Lie Shen, Hui Yang, Jia Ying, Fei Qiao & Mao Peng

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  1. Lie Shen
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  2. Hui Yang
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  3. Jia Ying
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  4. Fei Qiao
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  5. Mao Peng
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Correspondence to Lie Shen.

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Shen, L., Yang, H., Ying, J. et al. Preparation and mechanical properties of carbon fiber reinforced hydroxyapatite/polylactide biocomposites. J Mater Sci: Mater Med 20, 2259–2265 (2009). https://doi.org/10.1007/s10856-009-3785-2

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  • DOI: https://doi.org/10.1007/s10856-009-3785-2

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