Abstract
A successful total hip replacement has an expected service life of 10–20 years with over 75% of failures due to aseptic loosening which is directly related to cement mantle failure. The aim of the present study was to investigate the addition of nanoparticles of calcium carbonate to acrylic bone cement. It was anticipated that an improvement in mechanical performance of the resultant nanocomposite bone cement would be achieved. A design of experiment approach was adopted to maximise the mechanical properties of the bone cement containing nanoparticles of calcium carbonate and to determine the constituents and preparation methods for which these occur. The selected conditions provided improvements of 21% in energy to maximum load, 10% in elastic modulus, 7% in bending strength and 8% in bending modulus when compared with bone cement without nanoparticles. Although cement containing nanoCaCO3 coated in sodium citrate also enhanced the energy to maximum load by 28% and the elastic modulus by 14% when compared with control cement, it is not recommended as a factor in the production of nanocomposite bone cement due to reduction in the bending properties of the final bone cement.
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Abbreviations
- BPO:
-
Benzoyl peroxide
- DDS:
-
Drug delivery systems
- DOE:
-
Design of experiments
- DMPT:
-
N,N-Dimethyl-para-toluidene
- EDX:
-
Energy dispersive X-ray microanalysis
- HA:
-
Hydroxyapatite
- MMA:
-
Methyl methacrylate
- nanoBaSO4 :
-
Nanoparticulate barium sulphate
- nanoCaCO3 :
-
Nanoparticulate calcium carbonate
- PMMA:
-
Polymethyl methacrylate
- SA:
-
Stearic acid
- SC:
-
Sodium citrate
- SD:
-
Standard deviation
- SEM:
-
Scanning electron microscopy
- SPT:
-
Small punch test
- \( \ifmmode\expandafter\bar\else\expandafter\=\fi{X} \) :
-
Mean
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Acknowledgements
Nanoparticulate calcium carbonate used in the study was kindly provided by Professor Eileen Harkin-Jones of Queen’s University, Belfast.
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Hill, J., Orr, J. & Dunne, N. In vitro study investigating the mechanical properties of acrylic bone cement containing calcium carbonate nanoparticles. J Mater Sci: Mater Med 19, 3327–3333 (2008). https://doi.org/10.1007/s10856-008-3465-7
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DOI: https://doi.org/10.1007/s10856-008-3465-7