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Biodistribution of titanium dioxide from biologic compartments

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Abstract

The layer of titanium dioxide (TiO2) of the implant is chronically exposed to the internal electrolyte milieu in the peri-implant biological compartment. Corrosion results from electrochemical attack and ensuing gradual degradation of the metallic materials and is thus of biological interest when these biomaterials are employed in clinical implantology. Herein we evaluated and compared the chronic effect and the biodistribution of TiO2 administered subcutaneously or intraperitoneally. We propose that the compartmentalization of titanium in the area of subcutaneous injection would reproduce the biological compartment of the implant and its microenvironment from which metal ions could be released and migrate systemically. Potential TiO2 deposits were identified and characterized in skin, liver and lung by histological and EDX analyses. After both treatments, the skin, liver, and lungs exhibited histological evidence of TiO2 deposits. In order to characterize in situ macrophage-like cells, tissue sections were immunohistochemically stained for CD68. Tissue specimens from all organs assayed showed positive staining for anti-macrophage monoclonal antibody CD68 (PGM1). Despite the compartmentalization of titanium within nodular areas in rats treated subcutaneously, systemic migration occurred. We concluded that systemic migration of TiO2 occurred regardless of the administration route.

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Acknowledgements

The authors gratefully acknowledge the expert assistance of M.L. Paparella in the immunocytological evaluation. This study was supported by Grants: BID 1728/OC-AR—PICT 33493 from the National Agency for the Promotion of Science and Technology, O-020 from University of Buenos Aires, CONICET PIP6042 and Roemmers Foundation, Argentina.

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Authors and Affiliations

  1. Department of Oral Pathology, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina

    Daniel G. Olmedo, María Beatriz Guglielmotti & Rómulo Luis Cabrini

  2. National Research Council (CONICET), Buenos Aires, Argentina

    Daniel G. Olmedo & María Beatriz Guglielmotti

  3. Cátedra de Anatomía Patológica, Facultad de Odontología, Universidad de Buenos Aires, MT de Alvear 2142 2° A, C1122 AAH, Buenos Aires, Argentina

    Daniel G. Olmedo

  4. School of Science and Technology, University of General San Martin, Buenos Aires, Argentina

    Deborah R. Tasat

  5. Department of Radiobiology, National Atomic Energy Commission, Buenos Aires, Argentina

    Rómulo Luis Cabrini

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  1. Daniel G. Olmedo
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  2. Deborah R. Tasat
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  3. María Beatriz Guglielmotti
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  4. Rómulo Luis Cabrini
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Correspondence to Daniel G. Olmedo.

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Olmedo, D.G., Tasat, D.R., Guglielmotti, M.B. et al. Biodistribution of titanium dioxide from biologic compartments. J Mater Sci: Mater Med 19, 3049–3056 (2008). https://doi.org/10.1007/s10856-008-3438-x

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  • DOI: https://doi.org/10.1007/s10856-008-3438-x

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