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Development of two alginate-based wound dressings

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Abstract

Two types of new alginate-based wound dressings, Type-AP and Type-AE, were fabricated by the EDC-activated crosslinking of alginate with Polyethyleneimine and Ethylenediamine, respectively. As compared with the commercial non-woven wound dressing, Kaltostat®, both Type-AP and Type-AE dressings had higher degradation temperature, lower calcium content, and a sponge-like macroporous structure. In addition, these two alginate-based dressings had higher mechanical stress (12.37 ± 1.72 and 6.87 ± 0.5 MPa for Type-AP and -AE, respectively) and higher water vapor transmission rates (both about 3,500 g/m2/day) than KaltostatR (0.87 ± 0.12 MPa and 2,538 g/m2/day). Fibroblasts proliferated faster on these two newly developed wound dressings at a higher rate as compared with that on Kalostat® dressing. The results of animal study showed that the wounds treated with either Type-AP or Type-AE dressings healed faster than Kaltostat® with less encapsulation of residuals by fibrous tissue and more neo-capillary formation. These two newly developed Type-AP and Type-AE porous wound dressings thus have great potential for clinical applications.

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Authors and Affiliations

  1. Institute of Biomedical Engineering, National Yang Ming University, No. 155, Sec. 2, Li-Nung St., Beitou District, Taipei, 11221, Taiwan, ROC

    Chih-Tung Chiu, Yi-Pin Chang & Yng-Jiin Wang

  2. Department of Raw Materials and Yarn Formation Section, Taiwan Textile Research Institute, Tu-chen, Taipei, Taiwan, ROC

    Jui-Sheng Lee & Chi-Shung Chu

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  1. Chih-Tung Chiu
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  2. Jui-Sheng Lee
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  3. Chi-Shung Chu
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  5. Yng-Jiin Wang
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Correspondence to Yng-Jiin Wang.

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Chiu, CT., Lee, JS., Chu, CS. et al. Development of two alginate-based wound dressings. J Mater Sci: Mater Med 19, 2503–2513 (2008). https://doi.org/10.1007/s10856-008-3389-2

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  • DOI: https://doi.org/10.1007/s10856-008-3389-2

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