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Biomedical evaluation of polyvinyl alcohol–gelatin esterified hydrogel for wound dressing

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Abstract

The wound is a biosynthetic environment in which numerous cellular processes are interlinked in the process of repair. Modern dressings are designed to facilitate wound healing rather than just to cover it. Hydrogel dressing can protect injured skin and keep it appropriately moist to speed the healing process by absorbing exudates while maintaining the products of tissue repair, including growth factor and lysosomes, in contact with the wound. The design and development of novel membrane of hydrogels prepared by esterification of polyvinyl alcohol with gelatin were attempted. Contact angle of goat blood was determined. The hydrogel was characterized by hemolysis test and water vapor transmission rate. Diffusion coefficient of salicylic acid (SA) and gatifloxacin, a fourth generation fluoroquinolone, through the membrane was determined. Both the drugs were used as model drug. Methyl tetrazolium dye assay of the membrane was done using L929 fibroblast cell line and mice splenocytes to establish the biocompatibility of the membrane. The equilibrium goat blood-in-air contact angles of measured ester films ranged from 56 to 60°. The hydrogel was found to be hemocompatible and moisture retentive indicating its possible use in moist wound care. The diffusion coefficient of SA and gatifloxacin through the membrane was found to be 1.49 × 10−5 and 3.97 × 10−6 cm2/s respectively. The membrane was found to be compatible with the L929 fibroblast cell line and mice splenocytes.

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Acknowledgements

The authors are thankful to Indian Institute of Technology, Kharagpur, India for funding the research. The first author is also grateful to his lab-technician and lab-mates (Mr. N. K. Mallick, Mr. A. H. Bhat, Mr. Arfat Anis, Mr. Dibakar Behera, Ms. H. Satapathy, Dr. (Mrs.) S. Mondal and Mr. P. Pawar) for their constant encouragement and support during the completion of the work. The authors are also thankful to Department of Biotechnology, Indian Institute of Technology, Kharagpur for allowing to use their laboratory for cytocompatibility tests and Ranbaxy laboratories limited, India for supplying gatifloxacin as a gift.

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Authors and Affiliations

  1. Materials Science Centre, Indian Institute of Technology, Kharagpur, 721302, India

    Kunal Pal & A. K. Banthia

  2. Delhi Institute of Pharmaceutical Sciences & Research, Formerly College of Pharmacy, University of Delhi, Pushp Vihar, Sector-III, New Delhi, 110017, India

    D. K. Majumdar

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  1. Kunal Pal
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  2. A. K. Banthia
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  3. D. K. Majumdar
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Correspondence to A. K. Banthia.

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Pal, K., Banthia, A.K. & Majumdar, D.K. Biomedical evaluation of polyvinyl alcohol–gelatin esterified hydrogel for wound dressing. J Mater Sci: Mater Med 18, 1889–1894 (2007). https://doi.org/10.1007/s10856-007-3061-2

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  • DOI: https://doi.org/10.1007/s10856-007-3061-2

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