Skip to main content
SpringerLink
Log in

Synthesis of triclinic calcium pyrophosphate crystals

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

This paper presents a method for preparing crystals of triclinic calcium pyrophosphate (t-CPPD). A calcium pyrophosphate intermediate is first prepared by reaction of potassium pyrophosphate and calcium chloride. Samples of the intermediate are dissolved in hydrochloric acid and urea added. Upon heating to 95–100 °C, hydrolysis of the urea causes the pH to rise and t-CPPD crystallises out. Purity of the product was ascertained by chemical and physical analysis. Where large crystals are required an unstirred system is used, while smaller crystals are produced by stirring the reaction mixture.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. P. B. HALVERSON, Scanning Microsc. 6 (1992) 791

    CAS  Google Scholar 

  2. A. SWAN, B. R. HEYWOOD, B. CHAPMAN, H. SEWARD and P. A. DIEPPE, Ann. Rheum. Dis. 54 (1995) 825

    Article  CAS  Google Scholar 

  3. E. H. BROWN, J. R. LEHR, J. P. SMITH and A. W. FRAZIER, Agr. Food Chem. 11 (1963) 214

    Article  CAS  Google Scholar 

  4. G. S. MANDEL, K. M. RENNE, A. M. KOLBACH, W. D. KAPLAN, J. D. MILLER and N. S. MANDEL, J. Cryst. Growth 87 (1988) 453

    Article  CAS  Google Scholar 

  5. D. A. SKOOG, D. M. WEST and F. J. HOLLER, Fundamentals of Analytical Chemistry, 6th edn (Saunders: Fort Worth, 1992) p. 83

    Google Scholar 

  6. P. S. CHEN, T. Y. TORIBARA and H. WARNER, Anal. Chem. 28 (1956) 1756

    Article  CAS  Google Scholar 

  7. A. C. LARSON and R. B. VON DREELE, GSAS, General structure analysis system (Report, LAUR 86–748, Los Alamos National Laboratory, Los Alamos, 1986)

  8. N. S. MANDEL, Acta Cryst. B31 (1975) 1730

    CAS  Google Scholar 

  9. R. A. YOUNG, The Rietveld Method (Oxford: Oxford University Press, 1995)

    Google Scholar 

  10. P.-T. CHENG and K. P. H. PRITZKER, J. Rheumatol. 8 (1981) 772

    CAS  Google Scholar 

  11. P.-T. CHENG, K. P. H. PRITZKER, M. E. ADAMS, S. C. NYBURG and S. A. OMAR, J. Rheumatol. 7 (1980) 609

    CAS  Google Scholar 

  12. O. SÖHNEL and J. GARSIDE, Precipitation (Oxford: Butterworth-Heinemann, 1992) p. 271

    Google Scholar 

Download references

Acknowledgments

We thank Mrs M Marshall for carrying out the ion chromatography. The work was funded by a Project Grant from the Arthritis Research Council. Dr Wilson was supported by grant G9505593MA from the Medical Research Council of the U. K. Dr Shellis thanks Glaxo SmithKline PLC for financial support.

Author information

Authors and Affiliations

  1. Division of Restorative Dentistry, University of Bristol Dental School, Lower Maudlin Street, Bristol, BS1 2LY, UK

    P. J. Groves & R. P. Shellis

  2. Dental Biophysics, Francis Bancroft Building, Queen Mary, University of London, London, E1 4NS, UK

    R. M. Wilson

  3. MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Bristol, UK

    P. A. Dieppe

Authors
  1. P. J. Groves
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. M. Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. A. Dieppe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. P. Shellis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. P. Shellis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Groves, P.J., Wilson, R.M., Dieppe, P.A. et al. Synthesis of triclinic calcium pyrophosphate crystals. J Mater Sci: Mater Med 18, 1355–1360 (2007). https://doi.org/10.1007/s10856-007-0129-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-007-0129-y

Keywords

Search

Navigation