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Changed pattern of SERS hotspots by Ag nanoparticle growth under magnetic field for biomarker detection

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Abstract

As an important marker of Hepatocellular carcinoma (HCC), AFP-L3 has attracted attention. In this study, the surface-plasmon-assisted Ag nanoparticles symmetrical growth technology under magnetic field is used to fabricate the six-nanohole nanojar array containing Ag nanoparticles as the sensing substrate. The displacement of SERS signal of the optimized structure is used to detect HCC marker AFP-L3. This method has good stability, high accuracy and has great potential in the early diagnosis of HCC.

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Acknowledgements

This work is supported by the National Natural Science Foundation of China (No. 61675090, 61575080 and 51901060), Zhejiang Provincial Key Research and Development Program (Nos. 2019C01121).

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Author notes

  1. Yongjun Zhang and Xiaoyu Zhao contributed equally to this work.

Authors and Affiliations

  1. Center for Advanced Optoelectronic Materials, School of Material and Environmental Engineering, Hangzhou Dianzi University, Hangzhou, 310018, People’s Republic of China

    Yongjun Zhang, Xiaoyu Zhao, Wei Xu, Yaxin Wang & Jian Zhang

  2. Key Laboratory of Functional Materials Physics and Chemistry, Ministry of Education, College of Physics, Jilin Normal University, Changchun, 130103, People’s Republic of China

    Qi Zhu, Mingyu Cheng, Aonan Zhu & Xiaolong Zhang

  3. Department of Physics, Xiamen University, Xiamen, 361005, China

    Renxian Gao

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  1. Yongjun Zhang
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Correspondence to Yaxin Wang or Xiaolong Zhang.

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Zhang, Y., Zhao, X., Zhu, Q. et al. Changed pattern of SERS hotspots by Ag nanoparticle growth under magnetic field for biomarker detection. J Mater Sci 57, 6943–6952 (2022). https://doi.org/10.1007/s10853-022-07026-w

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