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Melt spinning of nano-hydroxyapatite and polycaprolactone composite fibers for bone scaffold application

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Abstract

Textile technology shows great advantages in tissue engineering applications and it is a promising candidate for bone scaffolds fabrication. Composite fibers made from nano-hydroxyapatite (nHA) particles and polycaprolactone (PCL) were prepared by the melt spinning technology. nHA particles with different concentrations (1, 3, 5 and 7 wt%) were loaded into PCL fibers, and their influence on fiber morphological, thermal, mechanical and biological performance was evaluated. Results indicated that nHA particles were homogeneously distributed in PCL fibers. And nHA loading improved the break stress and initial modulus of pure PCL fibers, as well as thermal stability, which was confirmed by thermogravimetric analysis. Mineral deposition was also observed on fibers with nHA loading, which was favorable to bone scaffolds. Tubular meshes made by weft knitting proved the manufacturability of nHA/PCL composite fibers for further scaffold applications.

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Acknowledgements

The project is support by the Fundamental Research Funds for the Central Universities (Grant Nos. 2232017A-05, 2232018G-01), the Science and Technology Support Program of Shanghai (Grant No. 16441903803), the Chinese Universities Scientific Fund (Grant No. CUSF-DH-D-2017012), the National Health and Family Planning Commission Fund (No. 2017ZX01001-S22) and the 111 project (Grant No. B07024).

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Authors and Affiliations

  1. College of Textiles, Donghua University, Shanghai, 201620, China

    Wen Xue, Peifeng Chen, Fujun Wang & Lu Wang

  2. Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Songjiang District, Shanghai, 201620, China

    Wen Xue, Peifeng Chen, Fujun Wang & Lu Wang

Authors
  1. Wen Xue
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  2. Peifeng Chen
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  3. Fujun Wang
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  4. Lu Wang
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Contributions

PC, FW and LW conceived and designed the experiments. WX and PC performed the experiments including fabrication and analysis. WX wrote the paper.

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Correspondence to Fujun Wang or Lu Wang.

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The authors declare no conflict of interest.

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Xue, W., Chen, P., Wang, F. et al. Melt spinning of nano-hydroxyapatite and polycaprolactone composite fibers for bone scaffold application. J Mater Sci 54, 8602–8612 (2019). https://doi.org/10.1007/s10853-019-03475-y

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  • DOI: https://doi.org/10.1007/s10853-019-03475-y

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