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Development of a resveratrol–zein–dopamine–lecithin delivery system with enhanced stability and mucus permeation

  • Materials for life sciences
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Abstract

The development of multi-functional nanoparticles is important in overcoming the poor stability and low mucus permeation of traditional drug delivery systems. Hence, the encapsulation of a model drug, resveratrol (RES), into zein–polydopamine–lecithin (ZPLs) nanoparticles was investigated through a delicately controlled phase separation process. The surface of the nanoparticles obtained was successfully modified with lecithin, which endowed them with neutral and hydrophilic properties. Due to the strong charge repulsion of the particles, the fabricated ZPLs showed high stability under the conditions of a saline solution, various pH, long-term storage and high-speed centrifugation. In vitro study suggested that the RES exhibited remarkably sustained release performance after loading into ZPLs. The quantificational experiment of the Transwell system suggested that most of the ZPLs could pass through mucus and exhibited high mucus permeation. This study provides a new opportunity to prepare RES-ZPLs nanospheres as a smart drug nanocarrier, with enhanced stability and mucus permeation.

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Abbreviations

C6:

Coumarin-6

DDS:

Drug delivery system

DL:

Drug loading

DLPC:

Dilauroylphosphatidylcholine

DLS:

Dynamic light scattering

DPPH:

1,1-Diphenyl-2-picryl-hydrazyl

FTIR:

Fourier transform infrared spectroscopy

LE:

Loading efficiency

PBS:

Phosphate buffered solution

PDA:

Polydopamine

PDI:

Polydispersity index

RES:

Resveratrol

SEM:

Scanning electron microscopy

SGF:

Simulated gastric fluid

SF:

Simulated fluids

SIF:

Simulated intestinal fluids

XPS:

X-ray photoelectron spectroscopy

ZPLs:

Zein–polydopamine–lecithin

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Acknowledgements

Financial support from the National Natural Science Foundation of China (Nos. 21476086 and 21776102) is greatly appreciated.

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Author notes

  1. Wenquan Huang and Shaomin Li have contributed equally to this work.

Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China

    Wenquan Huang, Shaomin Li, Zhixian Li, Wei Zhu, Shan Lu & Yanbin Jiang

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  1. Wenquan Huang
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  2. Shaomin Li
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  3. Zhixian Li
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  4. Wei Zhu
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Correspondence to Yanbin Jiang.

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Huang, W., Li, S., Li, Z. et al. Development of a resveratrol–zein–dopamine–lecithin delivery system with enhanced stability and mucus permeation. J Mater Sci 54, 8591–8601 (2019). https://doi.org/10.1007/s10853-019-03465-0

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