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Characterization and antimicrobial activity of a 2-O-methyl-β-cyclodextrin inclusion complex containing hexahydro-β-acids

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Abstract

An inclusion complex of hexahydro-β-acids (HBA) and 2-O-methyl-β-cyclodextrin (M-β-CD) was prepared using the grinding method to improve the water solubility of HBA. Complex formation was assessed using ultraviolet and visible light (UV–Vis) spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), nuclear magnetic resonance (1HNMR), and scanning electron microscopy (SEM). Results showed that the HBA molecule resided within the M-β-CD cavity. The water solubility test indicated that the effect of the M-β-CD encapsulation extended beyond increasing the solubility of HBA. Furthermore, the antibacterial activity of the HBA/M-β-CD inclusion complex, pure HBA, and M-β-CD against different food-related microorganisms was determined by an agar diffusion assay. Particularly, the HBA/M-β-CD inclusion complex exhibited better antibacterial activity against Listeria monocytogenes. These results suggest that incorporation of the HBA/M-β-CD inclusion complex in food might effectively inhibit L. monocytogenes growth.

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Acknowledgements

This work was sponsored by the National Natural Science Foundation of China (No. 31660490).

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Authors and Affiliations

  1. Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Ürümqi, 830046, Xinjiang, China

    Na Lu, Haining Xu & Yumei Liu

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  1. Na Lu
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  2. Haining Xu
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  3. Yumei Liu
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Correspondence to Yumei Liu.

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Lu, N., Xu, H. & Liu, Y. Characterization and antimicrobial activity of a 2-O-methyl-β-cyclodextrin inclusion complex containing hexahydro-β-acids. J Mater Sci 54, 4287–4296 (2019). https://doi.org/10.1007/s10853-018-3148-9

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  • DOI: https://doi.org/10.1007/s10853-018-3148-9

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