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Preparation and evaluation of liposomes encapsulating synthetic MMP inhibitor (Ro 28-2653)—cyclodextrin complexes

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Abstract

In this study, preparation and evaluation of liposomes, intended for intravenous administration, encapsulating synthetic MMP inhibitor (Ro 28-2653) – cyclodextrin complexes were realized. An increase in Ro solubility, via formation of binary (Ro/HPβCD) or ternary (Ro/HPβCD/L-lysine) complexes, permitted a similar increase in encapsulation efficiency of liposomes (Table 1). Moreover, Ro release kinetics depend on the encapsulation efficiency.

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Acknowledgements

This work was supported by the Ministry of the Walloon Region (Belgium). The authors are grateful to F. Sideri for her aid during the experimental work.

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Authors and Affiliations

  1. Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Liège, CHU, B36, avenue de l’Hôpital 1, 4000, Liege, Belgium

    Marie Piette, Delphine Castagne, Luc Delattre & Géraldine Piel

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  1. Marie Piette
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  2. Delphine Castagne
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  3. Luc Delattre
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  4. Géraldine Piel
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Correspondence to Marie Piette.

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Piette, M., Castagne, D., Delattre, L. et al. Preparation and evaluation of liposomes encapsulating synthetic MMP inhibitor (Ro 28-2653)—cyclodextrin complexes. J Incl Phenom Macrocycl Chem 57, 101–103 (2007). https://doi.org/10.1007/s10847-006-9214-y

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  • DOI: https://doi.org/10.1007/s10847-006-9214-y

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