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Novel chemo-enzymatic access to amphiphilic cyclodextrins

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Abstract

A new class of mono-substituted amphiphilic cyclodextrins was synthesized in a one-step lipase catalysed amidification. Microbial and animal lipases were able to catalyse this reaction. Depending on the acyl donors, various hydrophobic moieties have been grafted on methylated β-cyclodextrin. Azoninyl-methylated-β-cyclodextrin derivatives were also obtained by reaction of acetaldehyde and modified cyclodextrins in presence of dedicated lipase.

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Acknowledgements

This work was supported by le Conseil Régional de Picardie under the scientific “IBFBio” program. Grateful thanks to D. Lesur and S. Pilard (Plateforme Analytique, UPJV) for helpful discussion on aromatic compounds.

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Authors and Affiliations

  1. Laboratoire de Glucides, UMR 6219, Université de Picardie Jules Verne, 33 rue St Leu, Amiens Cedex, 80039, France

    Audrey Favrelle, Véronique Bonnet & Florence Djedaïni-Pilard

  2. Génie Enzymatique et Cellulaire, UMR 6022, Université de Picardie Jules Verne, Amiens, 80039, France

    Audrey Favrelle & Catherine Sarazin

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  1. Audrey Favrelle
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  2. Véronique Bonnet
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  3. Catherine Sarazin
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  4. Florence Djedaïni-Pilard
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Correspondence to Florence Djedaïni-Pilard.

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Favrelle, A., Bonnet, V., Sarazin, C. et al. Novel chemo-enzymatic access to amphiphilic cyclodextrins. J Incl Phenom Macrocycl Chem 57, 15–20 (2007). https://doi.org/10.1007/s10847-006-9167-1

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  • DOI: https://doi.org/10.1007/s10847-006-9167-1

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