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Spectral Characteristics of Bicalutamide Drug in Different Solvents and β-Cyclodextrin

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Abstract

Absorption and fluorescence spectra of bicalutamide (BCA) in different solvents and aqueous β-cyclodextrin (β-CD) solutions are reported. The solid inclusion complex of BCA with β-CD is prepared and investigated by FT-IR, 1H NMR, differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). The Stokes shift of BCA is correlated with various solvent polarity scales like E T(30), BK and f(D,n). β-CD studies show that (i) the absorption and emission maxima of BCA are shifted to red, (ii) the absorbance is slightly decreased whereas emission intensity is increased largely with an increasing β-CD concentration, (iii) BCA forms 1:1 inclusion complex with β-CD and (iv) intramolecular charge transfer (ICT) emission is present in the excited state.

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Acknowledgement

One of the author (N.R) is thankful to the Department of Science and Technology, New Delhi, for the financial support to the Project under Fast Track Proposal – Young Scientist Scheme No. SR/FTP/CS-14/2005 and University Grants Commission No. F-31-98/2005 (SR).

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Authors and Affiliations

  1. Department of Pharmacy, Annamalai University, Annamalainagar, Chidambaram, 608 002, Tamil Nadu, India

    A. Anton Smith, K. Kannan, R. Manavalan & N. Rajendiran

  2. Department of Chemistry, Annamalai University, Annamalainagar, Chidambaram, 608 002, Tamil Nadu, India

    N. Rajendiran

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  1. A. Anton Smith
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  2. K. Kannan
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  3. R. Manavalan
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  4. N. Rajendiran
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Correspondence to N. Rajendiran.

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Smith, A.A., Kannan, K., Manavalan, R. et al. Spectral Characteristics of Bicalutamide Drug in Different Solvents and β-Cyclodextrin. J Incl Phenom Macrocycl Chem 58, 161–167 (2007). https://doi.org/10.1007/s10847-006-9138-6

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  • DOI: https://doi.org/10.1007/s10847-006-9138-6

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