Skip to main content
SpringerLink
Log in

The short QT syndrome

  • Published:
Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Viskin, S., Zeltser, D., Ish-Shalom, M., et al. (2004). Is idiopathic ventricular fibrillation a short QT syndrome? Comparison of the QT intervals of patients with idiopathic ventricular fibrillation and healthy controls. Heart Rhythm, 1, 587–591.

    Article  PubMed  Google Scholar 

  2. Watanabe, H., Makiyama, T., Koyama, T., et al. (2010). High prevalence of early repolarization in short QT syndrome. Heart Rhythm, 7, 647–652.

    Article  PubMed  Google Scholar 

  3. Wolpert, C., Schimpf, R., Giustetto, C., et al. (2005). Further insights into the effect of quinidine in shortQT syndrome caused by a mutation in HERG. Journal of Cardiovascular Electrophysiology, 16, 54–58.

    Article  PubMed  Google Scholar 

  4. Vincent, G., Timothy, K., Leppart, M., et al. (1992). The spectrum of symptoms and QT intervals in carriers of the gene for the long QT syndrome. The New England Journal of Medicine, 327, 846–852.

    Article  PubMed  CAS  Google Scholar 

  5. Funada, A., Hayashi, K., Ino, H., et al. (2008). Assessment of QT intervals and prevalence of short QT syndrome in Japan. Clinical Cardiology, 31(6), 270–274.

    Article  PubMed  Google Scholar 

  6. Gallagher, M., Magliano, G., Yap, Y., et al. (2006). Distribution and prognostic significance of QT intervals in the lowest half centile in 12,012 apparently healthy persons. American Journal of Cardiology, 98(7), 933–935.

    Article  PubMed  Google Scholar 

  7. Kobza, R., Roos, M., Niggli, B., et al. (2009). Prevalence of long and short QT in a young population of 41,767 predominantly male Swiss conscripts. Heart Rhythm, 6, 652–657.

    Article  PubMed  Google Scholar 

  8. Maury, P., Extramiana, F., Spragia, P., et al. (2008). Short QT syndrome: update on a recent entity. Archives of Cardiovascular Diseases, 101, 779–786.

    Article  PubMed  Google Scholar 

  9. Schimpf, R., Wolpert, C., Gaita, F., et al. (2005). Short QT syndrome. Cardiovascular Research, 67, 357–366.

    Article  PubMed  CAS  Google Scholar 

  10. Giustetto, C., Di Monte, F., Wolpert, C., et al. (2006). Short QT syndrome: clinical findings and diagnostic-therapeutic implications. European Heart Journal, 27, 2440–2447.

    Article  PubMed  Google Scholar 

  11. Gaita, F., Giustetto, C., Bianchi, F., et al. (2003). Short QT syndrome: a familial cause of sudden death. Circulation, 108, 965–970.

    Article  PubMed  Google Scholar 

  12. Brugada, R., Hong, K., Dumaine, R., et al. (2004). Sudden death associated with short-QT syndrome linked to mutations in HERG. Circulation, 109, 30–35.

    Article  PubMed  CAS  Google Scholar 

  13. Grunnet, M., Diness, T., Hansen, R., et al. (2008). Biophysical characterization of the short QT mutation in hERG-N588K reveals a mixed gain- and loss-of-function. Cellular Physiology and Biochemistry, 22, 611–624.

    Article  PubMed  CAS  Google Scholar 

  14. Patel, C., & Antzelevitch, C. (2008). Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome. Heart Rhythm, 5, 585–590.

    Article  PubMed  Google Scholar 

  15. Bellocq, C., van Ginneken, A., Bezzina, C., et al. (2004). Mutation in the KCNQ1 gene leading to the short QT-interval syndrome. Circulation, 109, 2394–2397.

    Article  PubMed  Google Scholar 

  16. Priori, S., Pandit, S., Rivolta, I., et al. (2005). A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene. Circulation Research, 96(7), 800–807.

    Article  PubMed  CAS  Google Scholar 

  17. Wilde, A., & Tan, H. (2009). Inheritable potassium channel diseases. In D. Zipes & J. Jalife (Eds.), Cardiac Electrophysiology: From Cell to Bedside. Philadelphia: Saunders.

    Google Scholar 

  18. Antzelevich, C., Pollevick, G., Cordeiro, J., et al. (2007). Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation, 115, 442–449.

    Article  Google Scholar 

  19. Bowes, N. E., Bowes, K. R., & Towbin, J. A. (2000). The ‘final common pathway hypothesis’ and inherited cardiovascular disease. Herz, 25(3), 168–175.

    Article  Google Scholar 

  20. Antzelevich, C. (2007). Heterogeneity and cardiac arrhythmias: an overview. Heart Rhythm, 4, 964–972.

    Article  Google Scholar 

  21. Schimpf, R., Wolpert, C., Bianchi, F., et al. (2003). Congenital short QT syndrome and implantable cardioverter defibrillator treatment: inherent risk for inappropriate shock delivery. Journal of Cardiovascular Electrophysiology, 14, 1273–1277.

    Article  PubMed  Google Scholar 

  22. Antzelevitch, C. (2007). Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. AJP: Heart and Circulatory Physiology, 293, H2024–H2038.

    Article  CAS  Google Scholar 

  23. van Houzen, N., Alshiekh-Ali, A., Garlitski, A., et al. (2008). Short QT syndrome review. Journal of Interventional Cardiac Electrophysiology, 23, 1–5.

    Article  PubMed  Google Scholar 

  24. Gaita, F., Giustetto, C., Bianchi, F., et al. (2004). Short QT syndrome: pharmacological treatment. Journal of the American College of Cardiology, 43, 1494–1499.

    Article  PubMed  CAS  Google Scholar 

  25. Mizobuchi, M., Enjoji, Y., Yamamoto, R., et al. (2008). Nifekalant and disopyramide in a patient with shortQT syndrome: evaluation of pharmacological effects and electrophysiological properties. PACE, 31, 1229–1232.

    PubMed  Google Scholar 

  26. Gussak, I., Brugada, P., Brugada, J., et al. (2000). Idiopathic short QT interval: a new clinical syndrome? Cardiology, 94(2), 99–102.

    Article  PubMed  CAS  Google Scholar 

  27. Marbán, E. (2002). Cardiac channelopathies. Nature, 415, 213–218.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The New England Medical Cardiac Arrhythmia Center, Tufts Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA, 02111, USA

    Brian Cross, Munther Homoud, Mark Link, Caroline Foote, Ann C. Garlitski, Jonathan Weinstock & N. A. Mark Estes III

Authors
  1. Brian Cross
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Munther Homoud
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Caroline Foote
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ann C. Garlitski
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jonathan Weinstock
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. A. Mark Estes III
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. A. Mark Estes III.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cross, B., Homoud, M., Link, M. et al. The short QT syndrome. J Interv Card Electrophysiol 31, 25–31 (2011). https://doi.org/10.1007/s10840-011-9566-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10840-011-9566-0

Keywords

Search

Navigation