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Association of the IL4R single-nucleotide polymorphism I50V with recurrent spontaneous abortion (RSA)

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Background

Recurrent spontaneous abortion (RSA) is defined as three or more consecutive abortions before the 20th week of gestation. There is increasing evidence to support an immunological mechanism for the occurrence of RSA. The purpose of our study was to examine whether single-nucleotide polymorphisms (SNPs) of the interleukin-4 receptor gene IL4R influence susceptibility to, recurrent spontaneous abortion.

Materials and methods

This is a case-control study. We recruited 200 patients with RSA (case group) using established diagnostic criteria and 200, normal individuals (control group) at the fertility and infertility center in Yazd city and Isfahan city during 2012 to 2013. We screened the I50V variant in IL-4R in patients and controls by PCR-RFLF method, and we performed an association analysis between I50V variant and RSA.the data was analyzed by spss 16 software using Chi-square test.

Results

No differences in the genotype and allele frequencies of the I50V SNPs were identified between patients with RSA and healthy controls.

Conclusions

The frequency of SNP in IL-4 receptor (I50V) in patients with recurrent spontaneous abortion did not differ significantly compared with the control group. Analysis of IL4R SNP haplotypes or complex alleles suggested no dominant protection in patients with RSA.

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Authors and Affiliations

  1. Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Fataneh Tavasolian, Elham Abdollahi & Morteza Samadi

  2. Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Morteza Samadi

Authors
  1. Fataneh Tavasolian
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  2. Elham Abdollahi
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  3. Morteza Samadi
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Corresponding author

Correspondence to Morteza Samadi.

Additional information

Capsule Immunological disorder is a possible reason for Recurrent spontaneous abortion (RSA). I50V as a immunological genetic variant has no association with RSA. This is first report of frequency of I50V in RSA patients and related controls.

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Tavasolian, F., Abdollahi, E. & Samadi, M. Association of the IL4R single-nucleotide polymorphism I50V with recurrent spontaneous abortion (RSA). J Assist Reprod Genet 31, 851–856 (2014). https://doi.org/10.1007/s10815-014-0234-z

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  • DOI: https://doi.org/10.1007/s10815-014-0234-z

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