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A chromosome 19 locus positively influences the number of retrieved oocytes during stimulated cycles in Brazilian women

  • Genetics
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Abstract

Purpose

To evaluate if several genetic loci that are associated with variation in normal menopause age and early menopause can account for a poor response to controlled ovarian stimulation.

Methods

A total of 71 patients age ≤35 years old who were undergoing intracytoplasmic sperm injection were genotyped for four genetic variants that are associated with normal variation in menopausal age and early menopause. The patients were divided into two groups based upon treatment response: a poor responder group (PR group, n = 21) and a normal responder group (NR group, n = 50). The genetic variants rs244715, rs9379896, rs4806660 and rs16991615 were analyzed.

Results

There was no significant difference in the incidence of the genetic variants between the NR and PR group. The risk allele for the chromosome 19 variant (rs4806660) demonstrated a protective effect for a poor ovarian response. The presence of a risk allele was associated with an increased response to COS, which resulted in an elevated number of follicles (Coef: 2.54, P = 0.041) and retrieved oocytes (Coef: 1.41, P = 0.041).

Conclusions

The genetic variants rs244715, rs9379896, rs4806660 and rs16991615 are not risk factors for poor ovarian response in Brazilian women. In contrast, rs4806660 is associated with higher number of follicles and retrieved oocytes. rs4806660 may be associated with an increased response to gonadotrophin stimulation in this population.

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Authors and Affiliations

  1. Sapientiae Institute—Educational and Research Centre in Assisted Reproduction, Rua Vieira Maciel, 62, São Paulo, SP, Brazil, Zip: 04203-040

    Amanda Souza Setti, Sylvia Sanches Cortezzi, Daniela Paes de Almeida Ferreira Braga & Edson Borges Jr.

  2. Fertility—Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, São Paulo, SP, Brazil, Zip: 01401-002

    Rita de Cássia S. Figueira, Daniela Paes de Almeida Ferreira Braga, Assumpto Iaconelli Jr. & Edson Borges Jr.

  3. RDO—Medical Diagnosis, Av. Brasil, 1150, São Paulo, SP, Brazil, Zip: 01430-001

    Ciro Dresch Martinhago

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  1. Amanda Souza Setti
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  2. Sylvia Sanches Cortezzi
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  3. Rita de Cássia S. Figueira
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  4. Ciro Dresch Martinhago
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  6. Assumpto Iaconelli Jr.
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  7. Edson Borges Jr.
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Correspondence to Edson Borges Jr..

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Capsule

rs4806660 may be associated with an increased response to gonadotrophin stimulation in Brazilian women.

Amanda Souza Setti and Sylvia Sanches Cortezzi contributed equally to this article.

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Setti, A.S., Cortezzi, S.S., Figueira, R.d.C.S. et al. A chromosome 19 locus positively influences the number of retrieved oocytes during stimulated cycles in Brazilian women. J Assist Reprod Genet 29, 443–449 (2012). https://doi.org/10.1007/s10815-012-9735-9

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  • DOI: https://doi.org/10.1007/s10815-012-9735-9

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