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Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest.

Methods

Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls.

Results

The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001).

Conclusion

The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.

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Acknowledgments

This study was supported by Grants-in-Aid for Scientific Research (Nos 22591811, 22591812 and 20591902) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, to the Ministry of Health, Labour and Welfare of Japan.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan

    Toshinobu Miyamoto, Michiharu Horikawa & Kazuo Sengoku

  2. Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan

    Akira Tsujimura & Yasushi Miyagawa

  3. Department of Integrated Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

    Eitetsu Koh & Mikio Namiki

  4. Division of Community Medicine and Epidemiology, Department of Health Science, Asahikawa Medical University, Asahikawa, Japan

    Yasuaki Saijo

  5. Department of Obstetrics and Gynecology, Asahikawa Medical College, Midorigaokahigashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan

    Toshinobu Miyamoto

Authors
  1. Toshinobu Miyamoto
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  2. Akira Tsujimura
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  3. Yasushi Miyagawa
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  4. Eitetsu Koh
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  5. Mikio Namiki
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  6. Michiharu Horikawa
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  7. Yasuaki Saijo
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  8. Kazuo Sengoku
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Corresponding author

Correspondence to Toshinobu Miyamoto.

Additional information

Grants: Grants-in-Aid for Scientific Research (Nos 22591811, 22591812 and 20591902) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Ministry of Health, Labour and Welfare of Japan.

Capsule

c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia in Japanese men.

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Miyamoto, T., Tsujimura, A., Miyagawa, Y. et al. Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest. J Assist Reprod Genet 28, 743–746 (2011). https://doi.org/10.1007/s10815-011-9576-y

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  • DOI: https://doi.org/10.1007/s10815-011-9576-y

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