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The influence of early cleavage on embryo developmental potential and IVF/ICSI outcome

  • Assisted Reproduction
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To observe whether early cleavage can be a predictor of embryo developmental potential, pregnancy and implantation rates.

Methods

A total of 9,544 embryos in 1,095 in vitro fertilization or intracytoplasmic sperm injection cycles were observed with regard to the appearance of early cleavage at 25–29 h post-insemination.

Results

A significantly higher proportion of excellent quality embryos were observed in the early cleavage group compared to the late cleavage group (52.5 versus 28.9%, P < 0.01). In the early cleavage group there was also a higher rate of pregnancy per transfer compared with the late cleavage group (38.7 versus 26.3%, P < 0.01). In addition, we found that transfer of only one early cleavage embryo resulted in a high pregnancy rate (38.5%) and a low multiple pregnancy rate (18.0%).

Conclusion

Early cleavage is a strong indicator of embryo quality, and may be used as an additional criterion in the selection of embryos for transfer to increase pregnancy rate and reduce multiple pregnancy rate.

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Authors and Affiliations

  1. IVF Centre, International Peace Maternity & Child Health Hospital, Jiao Tong University Medical School, Shanghai, China

    Jing Fu, Xian-Jing Wang, Yong-Wei Wang, Jian Sun & Xiao-Xi Sun

  2. Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden

    Kristina Gemzell-Danielsson

Authors
  1. Jing Fu
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  2. Xian-Jing Wang
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  3. Yong-Wei Wang
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  4. Jian Sun
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  5. Kristina Gemzell-Danielsson
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  6. Xiao-Xi Sun
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Corresponding author

Correspondence to Xiao-Xi Sun.

Additional information

Capsule Analysis of a large sample cohort reinforces the value of early cleavage behavior as a useful predictor of developmental potential and IVF/ICSI outcome although the mechanisms underlying cell cycle acceleration remain unknown.

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Fu, J., Wang, XJ., Wang, YW. et al. The influence of early cleavage on embryo developmental potential and IVF/ICSI outcome. J Assist Reprod Genet 26, 437–441 (2009). https://doi.org/10.1007/s10815-009-9342-6

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  • DOI: https://doi.org/10.1007/s10815-009-9342-6

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