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GnRH agonist for triggering final oocyte maturation in patients at risk of ovarian hyperstimulation syndrome: still a controversy?

  • Assisted Reproduction
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Abstract

Purpose

An update on the subject of ovarian hyperstimulation syndrome (OHSS) prevention with GnRH agonist ovulation trigger.

Methods

Review of pertinent English language studies published during the past 4 years.

Results

Randomized prospective studies support the notion that agonist trigger completely eliminates OHSS. Conflicting results regarding on going pregnancy rate probably reflect different approaches to luteal phase support. Embryos obtained and frozen after agonist trigger yield good clinical outcome in subsequent thaw cycles.

Conclusions

The notion that agonist trigger can eliminate OHSS is strongly supported by randomized controlled trials. Further research is needed to assess optimal luteal support post agonist trigger.

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Acknowledgment

The authors are grateful to Mrs. Yakir Orly (Western Galilee Hospital) for the statistical analysis done for this paper.

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Authors and Affiliations

  1. Maccabi Health Services, Women Health Center, 10 Markoni Street, Haifa, Israel

    S. Kol & I. Solt

  2. IVF Unit, Rambam Medical Center, Haifa, Israel

    S. Kol

  3. Western Galilee Hospital, Nahariya, Israel

    I. Solt

Authors
  1. S. Kol
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  2. I. Solt
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Corresponding author

Correspondence to S. Kol.

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Kol, S., Solt, I. GnRH agonist for triggering final oocyte maturation in patients at risk of ovarian hyperstimulation syndrome: still a controversy?. J Assist Reprod Genet 25, 63–66 (2008). https://doi.org/10.1007/s10815-008-9198-1

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  • DOI: https://doi.org/10.1007/s10815-008-9198-1

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