Abstract
A family-based, cognitive behavioural treatment for anxiety in 47 children with comorbid anxiety disorders and High Functioning Autism Spectrum Disorder (HFA) was evaluated. Treatment involved 12 weekly group sessions and was compared with a waiting list condition. Changes between pre- and post-treatment were examined using clinical interviews as well as child-, parent- and teacher-report measures. Following treatment, 71.4% of the treated participants no longer fulfilled diagnostic criteria for an anxiety disorder. Comparisons between the two conditions indicated significant reductions in anxiety symptoms as measured by self-report, parent report and teacher report. Discussion focuses on the implications for the use of cognitive behaviour therapy with HFA children, for theory of mind research and for further research on the treatment components.

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Achenbach, T. M. (1985). Assessment of anxiety in children. In H. A. Tuma, & J. D. Maser (Eds.), Anxiety and the anxiety disorders (pp. 707–734). Hillsdale: Lawrence Erlbaum.
Albano, A. M., Chorpita, B. F., & Barlow, D. H. (2003). Childhood anxiety disorders. In E. J. Marsh, & R. A. Russell (Eds.), Child psychopathology (2nd ed., pp. 279–329). New York: Guildford.
Albano, A. M., & Kendall, P. C. (2002). Cognitive behavioural therapy for children and adolescents with anxiety disorders: Clinical research advances. International Review of Psychiatry, 14, 129–134.
Albano, A. M., & Silverman, W. K. (1996). Anxiety Disorders Interview Schedule for DSM-IV: Child version. Clinical manual. San Antonio: Psychological Corporation.
Alfano, C. A., Beidel, D. C., & Turner, S. M. (2002). Cognition in childhood anxiety: Conceptual methodological and developmental issues. Clinical Psychology Review, 22, 1209–1238.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington: Author.
Baron-Cohen, S. (2001). Theory of mind and autism: A review. In L. M. Glidden (Eds.), International review of research in mental retardation: Autism (pp. 169–184). San Diego: Academic.
Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985). Does the autistic child have a theory of mind? Cognition, 21, 37–46.
Barrett, P. M., Dadds, M. R., & Rapee R. M. (1996). Family treatment of childhood anxiety: A controlled trial. Journal of Consulting and Clinical Psychology, 64, 333–342.
Barrett, P. M., Duffy, A. L., Dadds, M. R., & Rapee, R. M. (2001). Cognitive-behavioral treatment of anxiety disorders in children: Long-term (6 year) follow-up. Journal of Consulting and Clinical Psychology, 69, 135–141.
Barrett, P. M., Rapee, R. M., Dadds, M. R., & Ryan, S. M. (1996). Family enhancement of cognitive style in anxious and aggressive children. Journal of Abnormal Child Psychology, 24, 187–203.
Barrett, P. M., & Turner, C. M. (2001). Prevention of anxiety symptoms in primary school children: Preliminary results from a universal school-based trial. British Journal of Clinical Psychology, 40, 399–410.
Barrett, P. M., & Turner, C. M. (2004). Prevention strategies. In T. L. Morris, & J. S. March (Eds.), Anxiety disorders in children and adolescents (pp. 371–387). New York: Guilford.
Bauminger, N., & Kasari, C. (1999). Brief report: Theory of mind in high-functioning children with autism. Journal of Autism and Developmental Disorders, 29, 81–86.
Beck, A. T. (1976). Cognitive therapy and the emotional disorders. New York: International Universities Press.
Beebe, D. W., & Risi, S. (2003). Treatment of adolescents and young adults with high-functioning autism or Asperger syndrome. In M. A. Reinecke, F. M. Dattilio, & A. Freeman (Eds.), Cognitive therapy with children and adolescents: A casebook for clinical practice (2nd ed., pp. 369–401). New York: Guilford.
Benjamin, R. S., Costello, E. J., & Warren, M. (1990). Anxiety disorders in a paediatric sample. Journal of Anxiety Disorders, 4, 851–855.
Bernstein, R. S., Costello, E. J., & Warren, M. (1990). Anxiety disorders in paediatric sample. Journal of Anxiety Disorders, 4, 293–316.
Bird, H. R. (1996). Epidemiology of childhood disorders in a cross-cultural context. Journal of Child Psychology and Psychiatry and Allied Disciplines, 37, 35–49.
Bowen, R. C., Offord, D. R., & Boyle, M. H. (1990). The prevalence of overanxious disorder and separation anxiety disorder: Results from the Ontario Child Health Study. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 753–758.
Bowler, D. M. (1992). “Theory of Mind” in Asperger’s syndrome. Journal of Child Psychology and Psychiatry, 33, 877–893.
Bowler, D. M., & Strom, E. (1999). Elicitation of first-order “theory of mind” in children with autism. Autism, 2, 33–44.
Braconnier, A. (1983). Autistic anxiety: Psychoanalytic approach. Neuropsychiatrie de L’Enfance et de L’Adolescence, 31, 255–256.
Brodkin, E. S., McDougle, C. J., Naylor, S. T., Cohen, D. J., & Price, L. H. (1997). Clomipramine in adults with pervasive developmental disorders: A prospective open-label investigation. Journal of Child and Adolescent Psychopharmacology, 7, 109–121.
Buitelaar, J. K., van der Wees, M., Swaab-Barneveld, H., & van der Gaag, J. R. (1999). Theory of mind and emotion-recognition functioning in autistic spectrum disorders and in psychiatric control and normal children. Development and Psychopathology, 11, 39–58.
Chalfant, A. M. (2004). Anxiety in children with High Functioning Autism Spectrum Disorders: Theoretical issues and treatment implications. Manuscript submitted for publication.
Chalfant, A. M., Franklin, J., & Rapee, R. M. (2004). The perception of anxious thoughts in children with an Autism Spectrum Disorder. Manuscript submitted for publication.
Chambless, D. L., & Hollon, S. D. (1998). Defining empirically supported therapies. Journal of Consulting and Clinical Psychology, 6, 7–18.
Clark, D. B., Smith, M. G., Neighbors, B. D., Skerlec, L. M., & Randall, J. (1994). Anxiety disorders in adolescence: Characteristics, prevalence, and co morbidities. Clinical Psychology Review, 14, 113–137.
Compton, S. N., Burns, B. J., Egger, H. L., & Robertson, E. (2002). Review of the evidence base for treatment of childhood psychopathology: Internalizing disorders. Journal of Consulting and Clinical Psychology, 70, 1240–1266.
Costello, E. J., Costello, A. J., Edelbrock, C., Burns, B. J., Dulcan M. K., Brent D., et al. (1988). Psychiatric disorders in paediatric primary care. Archives of General Psychiatry, 45, 1107–1116.
Coupland, N. J. (2001). Social phobia: Etiology, neurobiology and treatment. Journal of Clinical Psychiatry, 62(Suppl. 1), 25–35.
Craske, M. G. (1997). Fear and anxiety in children and adolescents. Bulletin of the Menninger Clinic, 61(Suppl. A), 4–36.
Dahlgren, S., Sandberg, A. D., & Hjelmquist, E. (2003). The non-specificity of theory of mind deficits: Evidence from children with communicative disabilities. European Journal of Cognitive Psychology, 15, 129–155.
Daleiden, E. L., & Vasey, M. W. (1997). An information-processing perspective on childhood anxiety. Clinical Psychology Review, 17, 407–429.
Dyck, M. J., Ferguson, K., & Shochet, I. M. (2001). Do autism spectrum disorders differ from each other and from non-spectrum disorders on emotion recognition tests? European Child and Adolescent Psychiatry, 10, 105–116.
Flannery-Schroeder, E. C., & Kendall, P. C. (2000). Group and individual cognitive-behavioral treatments for youth with anxiety disorders: A randomized clinical trial. Cognitive Therapy and Research, 24, 251–278.
Frith, U. (1989). Autism: Explaining the enigma. Oxford: Blackwell.
Gillot, A., Furniss, F., & Walter, A. (2001). Anxiety in high-functioning children with autism. Autism, 5, 277–286.
Goodman, R. (1997). The strengths and difficulties questionnaire: A research note. Journal of Child Psychology and Psychiatry, 38, 581–586.
Groden, J., Cautela, J., Prince, S., & Berryman, J. (1994). The impact of stress and anxiety on individuals with autism and developmental disabilities. In E. Schopler, & G. B. Mesibov (Eds.), Behavioral issues in autism. Current issues in autism (pp. 177–194). New York: Plenum.
Happé, F. G. E. (1994a). An advanced test of Theory of Mind: Understanding of story characters’ thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. Journal of Autism and Developmental Disorders, 24, 129–154.
Happé, F. G. E. (1994b). Annotation: Current psychological theories of autism: The “Theory of Mind” account and rival theories. Journal of Child Psychology and Psychiatry, 35, 215–229.
Happé, F. G. E. (1995). The role of age and verbal ability in the theory of mind task performance of subjects with autism. Child Development, 66, 843–855.
Happé, F. G. E., Briskman, J., & Frith, U. (2001). Exploring the cognitive phenotype of autism: Weak “central coherence” in parents and siblings of children with autism: I. Experimental tests. Journal of Child Psychology and Psychiatry and Allied Disciplines, 42, 299–307.
Heinemann, E. (1999). Psychoanalytic therapy with an autistic young man: A discussion of Frances Tustin’s theories. In J. De Groef, & E. Heinemann (Eds.), Psychoanalysis and mental handicap (pp. 23–40). London: Free Association Books.
Hirshfeld-Becker, D. R., & Biederman, J. (2002). Rationale and principles for early intervention with young children at risk for anxiety disorders. Clinical Child and Family Psychology Review, 5, 161–172.
Holroyd, S., & Baron-Cohen, S. (1993). Brief report: How far can people with autism go in developing a theory of mind? Journal of Autism and Developmental Disorders, 23, 379–385.
Jackson, H. J. (1983). Current trends in the treatment of phobias in autistic and mentally retarded persons. Australia and New Zealand Journal of Developmental Disabilities, 9, 191–208.
Kalus, O., Asnis, G. M., Ribinson, E., Kahn, R., Friedman, J. M. H., Iqbal, N., et al. (1991). Desipramine treatment in panic disorder. Journal of Affective Disorders, 21, 239–244.
Kashani, J. H., & Ovraschel, H. (1988). Anxiety disorders in mid-adolescence: A community sample. American Journal of Psychiatry, 145, 960–964.
Kashani, J. H., & Ovraschel, H. (1990). A community study of anxiety in children and adolescents. American Journal of Psychiatry, 147, 313–318.
Kashdan, T. B., & Herbert, J. D. (2001). Social anxiety disorder in childhood and adolescence: Current status and future directions. Clinical Child and Family Psychology Review, 4, 37–61.
Kazdin, A. E. (1986). Research designs and methodology. In S. L. Garfield, & A. E. Bergin (Eds.), Handbook of psychotherapy and behaviour change (3rd ed., pp. 23–69). New York: Wiley.
Kendall, P. C. (1985). Toward a cognitive-behavioural model of child psychopathology and a critique of related interventions. Journal of Abnormal Child Psychology, 13, 357–372.
Kendall, P. C. (1994). Treating anxiety disorders in children: Results of a randomised clinical trial. Journal of Consulting and Clinical Psychology, 62, 100–110.
Kendall, P. C. (2000). Child and adolescent therapy: Cognitive-behavioral procedures (2nd ed.). New York: Guilford.
Kendall, P. C., Flannery-Schroeder, E., Panichelli-Mindel, S., Southam-Gerow, M., Henin, A., & Warman, M. (1997). Therapy for youths with anxiety disorders: A second randomized clinical trial. Journal of Consulting and Clinical Psychology, 65, 366–380.
Kendall, P. C., Krain, A., & Treadwell, K. R. H. (1999). Generalized anxiety disorders. In R. T. Ammerman, M. Hersen, & C. G. Last (Eds.), Handbook of prescriptive treatments for children and adolescents (pp. 155–171). Needham Heights: Allyn & Bacon.
Kendall, P. C., & Morris, R. (1991). Child therapy: Issues and recommendations. Journal of Consulting and Clinical Psychology, 59, 777–784.
Kendall, P. C., & Ronan, K. R. (1990). Assessment of children’s anxieties, fears and phobias: Cognitive-behavioural models and methods. In C. R. Reynolds, & K. W. Kamphaus (Eds.), Handbook of psychological and educational assessment of children (pp. 223–244). New York: Guilford.
Kendall, P. C., Safford, S., Flannery-Schroeder, E., & Webb, A. (2004). Child anxiety treatment: Outcomes in adolescence and impact on substance use and depression at 7.4 year follow-up. Journal of Consulting and Clinical Psychology, 72, 276–287.
Kim, J. A., Szatmari, P., Bryson, S. E., Streiner, D. L., & Wilson, F. J. (2000). The prevalence of anxiety and mood problems among children with autism and Asperger syndrome. Autism, 4, 117–132.
Kleinman, J., Marciano, P. L., & Ault, R. L. (2001). Advanced theory of mind in high-functioning adults with autism. Journal of Autism and Developmental Disorders, 31, 29–36.
Lord, C. (1996). Treatment of a high-functioning adolescent with autism: A cognitive-behavioral approach. In M. A. Reinecke, F. M. Dattilio, & A. Freeman (Eds.), Cognitive therapy with children and adolescents: A casebook for clinical practice (pp. 394–404). New York: Guilford.
Lyneham, H. J., Abbott, M. J., Wignall, A., & Rapee, R. M. (2003). The Cool Kids family program—therapist manual. Sydney: Macquarie University.
Matson, J. L., & Love, S. R. (1990). A comparison of parent-reported fear for autistic and nonhandicapped age-matched children and youth. Australia and New Zealand Journal of Developmental Disabilities, 16, 349–357.
McDougle, C. J., Price, L. H., Volkmar, F. R., Goodman, W. K., Ward-O’Brien, D., Nielsen, J., et al. (1992). Clomipramine in autism: Preliminary evidence of efficacy. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 746–750.
Mendlowitz, S. L., Manassis, K., Bradley, S., Scapillato, D., Miezitis, S., & Shaw, B. F. (1999). Cognitive-behavioral group treatments in childhood anxiety disorders: The role of parental involvement. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 1223–1229.
Morgan, B., Maybery, M., & Durkin, K. (2003). Weak central coherence, poor joint attention, and low verbal ability: Independent deficits in early autism. Developmental Psychology, 39, 646–656.
Muris, P., Steerneman, P., Merckelbach, H., Holdrinet, I., & Meesters, C. (1998). Comorbid anxiety symptoms in children with pervasive developmental disorders. Journal of Anxiety Disorders, 12, 387–393.
Nauta, M., Scholing, A., Rapee, R., Abbott, M., & Spence, S. (2004). Development of a parent report measure of children’s anxiety: Psychometric properties and comparison with child report in a clinic and normal sample. Behaviour Research and Therapy, 42, 813–839.
Nicolson, R., Awad, G., & Sloman, L. (1998). An open trial of risperidone in young autistic children. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 372–376.
Ollendick, T. H. (1986). Behaviour therapy with children and adolescents. In S. Garfield, & A. Bergin (Eds.), Handbook of psychotherapy and behaviour change (3rd ed., pp. 525–565). New York: Wiley.
Ollendick, T. H., & King, N. J. (1998). Empirically supported treatments for children with phobic and anxiety disorders: Current status. Journal of Clinical Child Psychology, 27, 156–167.
Piacentini, J., & Bergman, R. L. (2001). Developmental issues in cognitive therapy for childhood anxiety disorders. Journal of Cognitive Psychotherapy, 15, 165–182.
Rapee, R. M. (2000). Group treatment of children with anxiety disorders: Outcome and predictors of treatment response. Australian Journal of Psychology, 52, 125–129.
Reynolds, C. R., & Richmond, B. O. (1978). What I think and feel: A revised measure of child’s manifest anxiety. Journal of Abnormal Child Psychology, 6, 271–280.
Rumsey, J. M., Rapoport, J. L., & Sceery, W. R. (1985). Autistic children as adults: Psychiatric social, and behavioral outcomes. Journal of the American Academy of Child and Adolescent Psychiatry, 24, 465–473.
Schniering, C. A., & Rapee, R. M. (2002). Development and validation of a measure of children’s automatic thoughts: The children’s automatic thoughts scale. Behaviour Research and Therapy, 40, 1091–1109.
Schteingart, A. (1989). Autism and separation anxiety. Revue Francaise de Psychanalyse, 53, 291–296.
Shortt, A. L., Barrett, P. M., & Fox, T. L. (2001). Evaluating the FRIENDS program: A cognitive-behavioural group treatment for anxious children and their parents. Journal of Clinical Child and Adolescent Psychology, 30, 525–535.
Silverman, W. K., Kurtines, W. M., Ginsburg, G. S., Weems, C. F., Lumpkin, P. W., & Carmichael, D. H. (1999a). Treating anxiety disorders in children with group cognitive–behavioral therapy: A randomized clinical trial. Journal of Consulting and Clinical Psychology, 67, 995–1003.
Silverman, W. K., Kurtines, W. M., Ginsburg, G. S., Weems, C. F., Rabian, B., & Serafini, L. T. (1999b). Contingency management, self-control, and education support in the treatment of childhood phobic disorders: A randomized clinical trial. Journal of Consulting and Clinical Psychology, 67, 675–687.
Silverman, W. K., Saavedra, L. M., & Pina, A. A. (2001). Test–retest reliability of anxiety symptoms and diagnoses with the anxiety disorders interview schedule for DSM-IV: Child and parent versions. Journal of American Academy of Child and Adolescent Psychiatry, 40, 937–943.
Spence, S. H. (1998). A measure of anxiety symptoms among children. Behaviour Research and Therapy, 36, 545–566.
Spence, S. H., Barrett, P. M., & Turner, C. M. (2003). Psychometric properties of the Spence Children’s Anxiety Scale with young adolescents. Journal of Anxiety Disorders, 17, 605–625.
Steffenburg, S., Gillberg, C., & Steffenburg, U. (1996). Psychiatric disorders in children and adolescents with mental retardation and active epilepsy. Archives of Neurology, 53, 904–912.
Tonge, B. J., Brereton, A. V., Gray, K. M., & Einfeld, S. L. (1999). Behavioural and emotional disturbance in high-functioning autism and Asperger syndrome. Autism, 3, 117–130.
Tsai, L. Y. (1999). Pharmacology in autism. Psychosomatic Medicine, 61, 651–665.
Verheij, F., & Van Loon, H. (1993). Pervasive developmental disorders not otherwise specified: A developmental-psychopathological approach for the development of made-to-measure treatment planning. European Journal of Child and Adolescent Psychiatry: Acta Paedopsychiatrica, 55, 235–242.
Vila, G., Nollet-Clemencon, C., de Blic, J., Mouren-Simeoni, M., & Scheinmann, P. (2000). Prevalence of DSM-IV anxiety and affective disorders in a paediatric population of asthmatic children and adolescents. Journal of Affective Disorders, 58, 223–231.
Weisz, J. R., Weiss, B., Han, S. S., Granger, D. A., & Morton, T. (1995). Effects of psychotherapy with children and adolescents revisited: A meta-analysis of treatment outcome studies. Psychological Bulletin, 117, 450–468.
Wing, L. (1976). Early Childhood Autism. London: Pergamon.
Wing, L. (1997). The history of ideas on autism. Autism, 1, 13–23.
Wolf, L. C., Noh, S., Fisman, S. N., & Speechly, M. (1989). Psychological effects of parenting stress on parents of autistic children. Journal of Autism and Developmental Disorders, 19, 157–166.
Yirmiya, N., Erel, O., Shaked, M., & Solomonica-Levi, D. (1998). Meta-analysis comparing theory of mind abilities of individuals with autism, individuals with mental retardation, and normally developing individuals. Psychological Bulletin, 124, 283–307.
Yirmiya, N., Solomonica-Levi, D., Shulman, C., & Pilowsky, T. (1996). Theory of mind abilities in individuals with autism, down syndrome, and mental retardation of unknown etiology: The role of age and intelligence. Journal of Child Psychology and Psychiatry, 37, 1003–1014.
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The authors gratefully acknowledge the financial support from Autism Spectrum Australia (“Aspect”) and the St George Foundation. Also, thanks go to all the children and parents who made the research possible.
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Chalfant, A.M., Rapee, R. & Carroll, L. Treating Anxiety Disorders in Children with High Functioning Autism Spectrum Disorders: A Controlled Trial. J Autism Dev Disord 37, 1842–1857 (2007). https://doi.org/10.1007/s10803-006-0318-4
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DOI: https://doi.org/10.1007/s10803-006-0318-4