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The visual impact of higher-order aberrations in patients with pediatric blepharokeratoconjunctivitis

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Abstract

Purpose

To analyze higher-order aberrations (HOAs) and their visual impact in a pediatric blepharokeratoconjunctivitis (PBKC) cohort compared with healthy controls.

Methods

Prospective case–control study of pediatric patients (≤ 16 years old). Subjects underwent wavefront aberrometry analysis to compare HOAs and their impact on visual quality.

Results

A total of 150 eyes from 76 patients were included in the analysis. The PBKC group consisted of 50 eyes and the control group of 100 healthy eyes. Mean age was 10.39 ± 3.81 years for the PBKC group and 10.80 ± 3.61 years for the controls. Mean corrected-distance visual acuity (CDVA) was 0.24 ± 0.21 logMAR in the PBKC group and 0.07 ± 0.1 in the controls (P < 0.001). Mean astigmatism was 1.6 ± 1.98D in the PBKC group vs. 0.67 ± 0.76D in the control group (P = 0.01). Mean RMS of HOAs was 1.05 ± 1.7mm in the PBKC group and 0.41 ± 0.18mm in the controls (P < 0.001). The mean modulation transfer function (MTF) in the PBKC group was significantly lower (16.37 ± 16.32) than controls (30.3 ± 23.57) (P < 0.001). Corneal leukomas, stromal vascularization, peripheral nummular subepithelial scars, and pannus formation are associated with increased HOAs.

Conclusions

There was a significant increase in total HOAs of eyes with PBKC compared to healthy controls. Corneal opacity, vascularization, and scarring are associated with increased HOAs. The PBKC eye aberration profile: coma, secondary astigmatism, quadrafoil, and pentafoil, were associated with decreased CDVA and visual quality (PSF and MTF).

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

Salomon Alvarado-Ramos M.D. for his contribution to statistical assistance.

Funding

This research project was partially funded by The Immuneye Foundation of Monterrey, Mexico.

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Authors and Affiliations

  1. Tecnologico de Monterrey, School of Medicine and Health Sciences. Institute of Ophthalmology and Visual Sciences, Av. Batallon de San Patricio #112. Col. Real de San Agustin, N.L., CP. 66278, Monterrey, Mexico

    Carolina Mendoza-Zamora, Sara Gonzalez-Godinez, Gustavo Ortiz-Morales, Juan Homar Paez-Garza & Alejandro Rodriguez-Garcia

Authors
  1. Carolina Mendoza-Zamora
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  2. Sara Gonzalez-Godinez
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  3. Gustavo Ortiz-Morales
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  4. Juan Homar Paez-Garza
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  5. Alejandro Rodriguez-Garcia
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Contributions

Conceptualization (SGG, ARG), methodology (SGG, CMZ, GOM), validation (SGG, JHPG, ARG), formal analysis (CMZ, SGG, GOM), investigation (CMZ, SGG, GOM, JHPG, ARG), resources (JHPG, ARG), data curation (CMZ, GOM, SGG), writing—original draft (CMZ, SGG, GOM, ARG), writing—review and editing (CMZ, SGG, GOM, ARG), visualization (SSG, JHPG, ARG), supervision (SGG, JHPG, ARG), project administration (ARG).

Corresponding author

Correspondence to Alejandro Rodriguez-Garcia.

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Conflict of interest

The authors declare that they have no competing financial interests.

Ethical approval

This study was approved by the Ethics (license no. P000172-BLE-STAFF-CEIC-271-CR001), and Research (license No. P000172-BLE-STAF-CI-CR001) Committees at our institution (license No. CONBIOETICA 19 CEI 011-2016-10-17 and COFEPRIS 20 CI 19 039 002, respectively), following the tenets of the Declaration of Helsinki.

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Informed consent from all patients´ parents was obtained.

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Mendoza-Zamora, C., Gonzalez-Godinez, S., Ortiz-Morales, G. et al. The visual impact of higher-order aberrations in patients with pediatric blepharokeratoconjunctivitis. Int Ophthalmol 44, 60 (2024). https://doi.org/10.1007/s10792-024-03002-2

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