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Optical coherence tomography angiography findings in pediatric patients with graves ophthalmopathy

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Abstract

Purpose

The aim of this study was to evaluate peripapillary, macular microvascular structure, and retinal nerve fiber layer (RNFL) thickness profile in children with Graves Ophthalmopathy (GO).

Material and methods

Thirty-six eyes of 18 children with GO were prospectively compared with 40 eyes of 20-age and sex-matched controls. The severity and activity of the disease were evaluated according to the criteria of the European Group on Graves’ Ophthalmopathy (EUGOGO) and Clinical Activity Score (CAS). After complete ophthalmologic and endocrinologic examination, all patients underwent optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) measurements. Retinal nerve fiber layer (RNFL) thickness, macular superficial capillary plexus (SCP), deep capillary plexus (DCP), foveal avascular zone (FAZ) area, acircularity index (AI) of the FAZ and peripapillary microvascular structure were analyzed.

Results

The mean age was 12.1 ± 2.4 years in the GO group and 11.2 ± 2.6 years in healthy control group (p = 0.11). Duration of disease was 8.9 ± 4.2 months in the GO group. All patients in GO group had mild and inactive ophthalmopathy. In temporal inferior quadrant, RNFL thickness was significantly thinner in the GO group compared to the control group (p = 0.03). No significant difference was seen between groups both peripapillary and macular microvascular structure (all p > 0.05).

Conclusion

GO has no effect on optic nerve thickness, peripapillary and macular vascular parameters except inferior temporal RNFL in children.

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Authors and Affiliations

  1. University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey

    Kubra Serbest Ceylanoglu & Emine Malkoc Sen

  2. University of Health Sciences, Dr. Sami Ulus Obstetrics and Gynaecology, Children’s Health and Disease Education and Research Hospital, Ophthalmology Department, Ankara, Turkey

    Selin Sahin Karamert

  3. University of Health Science, Dr. Sami Ulus Obstetrics and Gynaecology, Children’s Health and Disease Education and Research Hospital, Clinic of Pediatric Endocrinology, Ankara, Turkey

    Senay Savas Erdeve & Semra Cetinkaya

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  1. Kubra Serbest Ceylanoglu
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  2. Emine Malkoc Sen
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  4. Senay Savas Erdeve
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  5. Semra Cetinkaya
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Contributions

The authors confirm contribution to the paper as follows: study conception and design: K.S.C., S.S.K , E.M.S ; data collection: K.S.C., S.S.K.,S.S.E, S.C; analysis and interpretation of results:K.S.C, E.M.S.; draft manuscript preparation: K.S.C., E.M.S. All authors reviewed the results and approved the final version of the manuscript.

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Correspondence to Kubra Serbest Ceylanoglu.

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The authors declare that they have no affiliations with or involvement in any organization or entity with any financial or non-financial interest in the subject matter or materials discussed in this manuscript.

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All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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We obtained consent for publication from each patient parent or guardian.

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Ceylanoglu, K.S., Sen, E.M., Karamert, S.S. et al. Optical coherence tomography angiography findings in pediatric patients with graves ophthalmopathy. Int Ophthalmol 43, 3609–3614 (2023). https://doi.org/10.1007/s10792-023-02769-0

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  • DOI: https://doi.org/10.1007/s10792-023-02769-0

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