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Reduced tear break-up time in the fellow eye of patients with unilateral primary acquired nasolacrimal duct obstruction

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Abstract

Purpose

To measure tear osmolarity, Schirmer I test and tear break-up time (TBUT) values in the obstructed and non-obstructed fellow eye of unilateral primary acquired nasolacrimal duct obstruction (PANDO) patients and compare them with healthy controls.

Methods

In this prospective noninterventional study, the tear osmolarity, Schirmer I test, and TBUT values from unilateral PANDO eyes, fellow eyes, and control eyes of all subjects were measured.

Results

The study included 114 eyes of 30 PANDO patients as well as 27 healthy controls. There was a significant difference between TBUT and Schirmer values of fellow eyes and PANDO eyes (p = 0,035; p = 0,001). There was no significant difference in any of the ocular surface parameters between PANDO eyes and control eyes (p > 0.05). When fellow eyes were compared to control eyes, there was a significant difference in TBUT (p = 0.046).

Conclusions

Decreased TBUT was exhibited by the fellow eye of unilateral PANDO patients, compared to the PANDO side and controls. Compensatory changes in PANDO eyes due to a decrease in the tear secretion reflex may lead to tear dysfunction of the fellow eye. Clinicians should assess tear stability in the fellow eye of PANDO patients as this could be leading to added symptomatic complaints.

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References

  1. Ali MJ, Paulsen F (2019) Etiopathogenesis of primary acquired nasolacrimal duct obstruction: what we know and what we need to know. Ophthalmic Plast Reconstr Surg 35(5):426–433. https://doi.org/10.1097/IOP.0000000000001310

    Article  PubMed  Google Scholar 

  2. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC (1998) The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17(6):584–589. https://doi.org/10.1097/00003226-199811000-00002

    Article  CAS  PubMed  Google Scholar 

  3. Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC (2004) The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res 78(3):409–416. https://doi.org/10.1016/j.exer.2003.09.003

    Article  CAS  PubMed  Google Scholar 

  4. Dartt DA (2009) Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog Retin Eye Res 28(3):155–177. https://doi.org/10.1016/j.preteyeres.2009.04.003

    Article  PubMed  PubMed Central  Google Scholar 

  5. Pflugfelder SC, de Paiva CS (2017) The pathophysiology of dry eye disease: what we know and future directions for research. Ophthalmology 124(11S):S4–S13. https://doi.org/10.1016/j.ophtha.2017.07.010

    Article  PubMed  Google Scholar 

  6. Craig JP, Nichols KK, Akpek EK et al (2017) TFOS DEWS II definition and classification report. Ocul Surf 15(3):276–283. https://doi.org/10.1016/j.jtos.2017.05.008

    Article  PubMed  Google Scholar 

  7. Yen MT, Pflugfelder SC, Feuer WJ (2001) The effect of punctal occlusion on tear production, tear clearance, and ocular surface sensation in normal subjects. Am J Ophthalmol 131(3):314–323. https://doi.org/10.1016/s0002-9394(00)00822-9

    Article  CAS  PubMed  Google Scholar 

  8. Yazici A, Bulbul E, Yazici H et al (2015) Lacrimal gland volume changes in unilateral primary acquired nasolacrimal obstruction. Invest Ophthalmol Vis Sci 56(8):4425–4429. https://doi.org/10.1167/iovs.15-16873

    Article  PubMed  Google Scholar 

  9. Tomlinson A, Khanal S, Ramaesh K et al (2006) Tear film osmolarity: determination of a referent for dry eye diagnosis. Invest Ophthalmol Vis Sci 47(10):4309–4315. https://doi.org/10.1167/iovs.05-1504

    Article  PubMed  Google Scholar 

  10. Stahl U, Willcox M, Stapleton F (2012) Osmolality and tear film dynamics. Clin Exp Optom 95(1):3–11. https://doi.org/10.1111/j.1444-0938.2011.00634.x

    Article  PubMed  Google Scholar 

  11. Stahl U, Francis IC, Stapleton F (2006) Prospective controlled study of vapor pressure tear osmolality and tear meniscus height in nasolacrimal duct obstruction. Am J Ophthalmol 141(6):1051–1056. https://doi.org/10.1016/j.ajo.2005.12.051

    Article  PubMed  Google Scholar 

  12. Yuksel N, Akcay E, Ayan B, Duru N (2017) Tear-film osmolarity changes following dacryocystorhinostomy in primary acquired nasolacrimal duct obstruction. Curr Eye Res 42(3):348–350. https://doi.org/10.1080/02713683.2016.1196706

    Article  PubMed  Google Scholar 

  13. Saleh GM, Hussain B, Woodruff SA, Sharma A, Litwin AS (2012) Tear film osmolarity in epiphora. Ophthalmic Plast Reconstr Surg 28(5):338–340. https://doi.org/10.1097/IOP.0b013e31825e6960

    Article  PubMed  Google Scholar 

  14. M’Garrech M, Rousseau A, Kaswin G, Sauer A, Barreau E, Bourcier T, Labetoulle M (2013) Impairment of lacrimal secretion in the unaffected fellow eye of patients with recurrent unilateral herpetic keratitis. Ophthalmology 120(10):1959–1967. https://doi.org/10.1016/j.ophtha.2013.02.037

    Article  PubMed  Google Scholar 

  15. Francis IC, Chan DG, Papalkar D, Papas EB, Stapleton F (2005) Videoreflective dacryomeniscometry in normal adults and in patients with functional or primary acquired nasolacrimal duct obstruction. Am J Ophthalmol 139(3):493–497. https://doi.org/10.1016/j.ajo.2004.10.017

    Article  PubMed  Google Scholar 

  16. Park DI, Lew H, Lee SY (2012) Tear meniscus measurement in nasolacrimal duct obstruction patients with Fourier-domain optical coherence tomography: novel three-point capture method. Acta Ophthalmol 90(8):783–787. https://doi.org/10.1111/j.1755-3768.2011.02183.x

    Article  PubMed  Google Scholar 

  17. Wang J, Palakuru JR, Aquavella JV (2008) Correlations among upper and lower tear menisci, noninvasive tear break-up time, and the Schirmer test. Am J Ophthalmol 145(5):795–800. https://doi.org/10.1016/j.ajo.2007.12.035

    Article  PubMed  PubMed Central  Google Scholar 

  18. Tung CI, Perin AF, Gumus K, Pflugfelder SC (2014) Tear meniscus dimensions in tear dysfunction and their correlation with clinical parameters. Am J Ophthalmol 157(2):301-310.e1. https://doi.org/10.1016/j.ajo.2013.09.024

    Article  PubMed  Google Scholar 

  19. Zengin N (1993) The effect of dacryocystorhinostomy on tear film flow and stability in patients with chronic dacryocystitis. Acta Ophthalmol 71(5):714–716. https://doi.org/10.1111/j.1755-3768.1993.tb04669.x

    Article  CAS  Google Scholar 

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Ophthalmology Department, Dr. Ersin Arslan’s Research and Education Hospital, Gaziantep, Turkey

    Nesime Setge Tıskaoğlu & Alper Yazıcı

  2. Ophthalmology Department, İzmir Torbalı State Hospital, İzmir, Turkey

    Nesime Setge Tıskaoğlu & Alper Yazıcı

Authors
  1. Nesime Setge Tıskaoğlu
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  2. Alper Yazıcı
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Contributions

AY was responsible for the study’s conception and design. Data collection and analysis were performed by NST. The first draft of the manuscript was written by NST, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Nesime Setge Tıskaoğlu.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the University of Balıkesir (Date 08/2014-No. 23/2014).

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Informed consent was obtained from all individual participants included in the study.

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Tıskaoğlu, N.S., Yazıcı, A. Reduced tear break-up time in the fellow eye of patients with unilateral primary acquired nasolacrimal duct obstruction. Int Ophthalmol 43, 965–971 (2023). https://doi.org/10.1007/s10792-022-02498-w

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  • DOI: https://doi.org/10.1007/s10792-022-02498-w

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