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Evaluation of choroidal thickness and ocular manifestations in lipoid proteinosis

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Abstract

Purpose

To assess choroidal thickness in patients with lipoid proteinosis versus healthy subjects using enhanced depth imaging optical coherence tomography.

Methods

Twenty eyes of 20 patients and the same number of age and sex-matched healthy individuals were enrolled. Comprehensive ocular examinations including measurement of best-corrected visual acuity, spherical equivalent values of refractive errors, and axial length were performed. Choroidal thickness at three points (subfoveal, 500 µm nasal and temporal regions) were measured automatically using MATLAB software.

Results

The mean age was 15.68 ± 5.98 years in the patient group and 16.48 ± 5.69 years in the control group. Mean choroidal thickness was statistically significantly thicker at each point in patients with lipoid proteinosis compared to the healthy controls: subfoveal, temporal and nasal choroidal thickness measurements were 425.65 ± 51.42, 380.20 ± 69.66, 334.05 ± 49.98 µm in the study group; 346.15 ± 47.76, 330.15 ± 44.35, 298.95 ± 44.21 µm in the control group, respectively (P < 0.05).

Conclusion

Patients with lipoid proteinosis have thicker choroid compared to control eyes. Hyalin deposition and ensuing potential inflammation in the disease process may explain this finding.

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Data availability

All data generated or analyzed during this study are included in this article.

Code availability

None.

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Acknowledgements

The authors would like to thank Dr.Furkan Çiftçi and Engineer Hüseyin Güven Abalı for choroidal thickness measurements and Dr.Elifcan Taşdelen for pedigree figure.

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Authors and Affiliations

  1. Department of Ophthalmology, Şanlıurfa Training and Research Hospital, Şanlıurfa, Turkey

    Armağan Özgür

  2. Department of Dermatology, Şanlıurfa Training and Research Hospital, Şanlıurfa, Turkey

    İsa An

Authors
  1. Armağan Özgür
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  2. İsa An
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Corresponding author

Correspondence to Armağan Özgür.

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Informed consent was obtained from the participants or their parents.

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Informed consent was obtained from the all authors.

Ethical approval

The study followed the tenets of the Declaration of Helsinki and was approved by the local ethics committee. (Approval number: HRU/20.16.13).

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Cite this article

Özgür, A., An, İ. Evaluation of choroidal thickness and ocular manifestations in lipoid proteinosis. Int Ophthalmol 43, 239–247 (2023). https://doi.org/10.1007/s10792-022-02422-2

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  • DOI: https://doi.org/10.1007/s10792-022-02422-2

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