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Changes in the peripapillary and subfoveal choroidal vascularity index after transsphenoidal surgery for pituitary macroadenoma

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Abstract

Purpose

To investigate the changes in peripapillary and subfoveal choroidal vascular indexes (CVI) before and after pituitary macroadenoma surgery by using a binarization method.

Method

In this cross-sectional study, we examined 17 eyes in 9 patients with pituitary macroadenomas who had undergone transsphenoidal pituitary surgery due to chiasmal compression. We also compiled data from 17of in 17 healthy subjects. ImageJ 1.51 software processing (National Institutes of Health, Bethesda, Maryland, USA) was used for binarization of optical coherence tomography scans. The CVI was computed as the ratio of luminal area to total choroidal areal. The CVI, OCT and VF parameters were analyzed in One-Way Repeated Measures ANOVA to determine significant changes in measurements during the postoperative course.

Results

The mean peripapillary inferior and temporal quadrant CVIs were significantly lower in the eyes of patients with pituitary macroadenoma compared to controls (46.0 ± 0.03 versus. 42.8 ± 0.04, p = 0.02; 45.8 ± 0.03 Versus. 42.3 ± 0.04, p = 0.02). In repeated measure analysis, there was a significant effect of transsphenoidal microscobic pituitary surgery on peripapillary inferior quadrant CVI and BCVA, F(1.3, 21.5) = 6.62, p = 0.01 and F (1.8, 29.7) = 7.8, p < 0.005, respectively.

Conclusion

This study suggests that PMa with chiasmal compression may lead to significant changes in the peripapillary CVI. Pituitary surgery had a favorable significant effect on peripapillary choroidal vascular network and BCVA. Furthermore, optical coherence tomography is a helpful technique for quantifying the alterations of peripapillary CVI during the preoperative and postoperative course.

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Data availability

Data are available upon reasonable request from the authors.

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Acknowledgements

The authors thank Julie Yamamoto for editorial assistance.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Ophthalmology, Baskent University School of Medicine/Yeditepe University School of Medicine, Istanbul, Turkey

    Yasin Özcan

  2. Department of Ophthalmology, Yeditepe University School of Medicine, Istanbul, Turkey

    Alp Kayıran

  3. Department of Internal Medicine and Endocrinology, Yeditepe University School of Medicine, Istanbul, Turkey

    Fahrettin Kelestimur

  4. Department of Radiology, Yeditepe University School of Medicine, Istanbul, Turkey

    Gazanfer Ekinci

  5. Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey

    Uğur Türe

Authors
  1. Yasin Özcan
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  2. Alp Kayıran
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  3. Fahrettin Kelestimur
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  4. Gazanfer Ekinci
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  5. Uğur Türe
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Correspondence to Yasin Özcan.

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Özcan, Y., Kayıran, A., Kelestimur, F. et al. Changes in the peripapillary and subfoveal choroidal vascularity index after transsphenoidal surgery for pituitary macroadenoma. Int Ophthalmol 42, 3691–3702 (2022). https://doi.org/10.1007/s10792-022-02366-7

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  • DOI: https://doi.org/10.1007/s10792-022-02366-7

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