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Evaluation of augmentation index and pulse wave velocity measurements in central retinal vein occlusion patients with and without hypertension

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Abstract

Purpose

To evaluate arterial stiffness using the pulse wave velocity (PWV) and augmentation index (AI) in central retinal vein occlusion (CRVO) patients.

Methods

Forty-two CRVO patients (i.e., CRVO group) and 54 healthy controls (i.e., control group) were included in this comparative and cross-sectional study. The PWV, AI and augmentation pressure were measured with a noninvasive, oscillometric method.

Results

The mean PWV, AI and augmentation pressure values were significantly higher in CRVO patients than in controls (p = 0.024, p < 0.001 and p = 0.001, respectively). The mean augmentation pressure, AI and PWV measurements were not statistically significant between CRVO patients with and without hypertension (p = 0.856 and p < 0.526, p = 0.432, respectively). Age, presence of hypertension, AI and PWV were found to be as independent risk factors of CRVO development (OR = 2.21, 95% CI [1.44, 3.38] and OR = 2.40, 95% CI [1.50, 3.86], OR = 3.2, 95% CI [1.70, 5.60] and OR = 5.70, 95% CI [2.00, 18.50], respectively).

Conclusion

The AI and PWV values were significantly higher in CRVO patients than in controls. These results indicate that similar abnormalities in the arterial wall structure may play an important role in the pathogenesis of the CRVO and cardiovascular diseases. In addition, our findings show that each patient with RVO should be examined in terms of systemic vascular pathologies.

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Acknowledgements

I’d like to acknowledge the help of Sertan Göktas. He has always supported and nurtured me with his generous comments and kindness.

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No author has a financial or proprietary interest in any material or method mentioned.

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Authors and Affiliations

  1. Department of Ophthalmology, The Dünya Göz Hospital, Gaziantep, Turkey

    Mehmet Fatih Karadağ

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  1. Mehmet Fatih Karadağ
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Correspondence to Mehmet Fatih Karadağ.

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Karadağ, M.F. Evaluation of augmentation index and pulse wave velocity measurements in central retinal vein occlusion patients with and without hypertension. Int Ophthalmol 42, 1347–1354 (2022). https://doi.org/10.1007/s10792-022-02237-1

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