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Smoking effect on peripapillary and macular microvascular structure in inactive Graves’ ophthalmopathy

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Abstract

Objective

The aim of this study was to evaluate the smoking effect on peripapillary and macular microvascular structure in patients with inactive Graves’ ophthalmopathy (GO) and to compare these structures with those of healthy control subjects.

Methods

A total of 34 healthy participants (control group), 22 inactive GO patients with smoking (smoker group) and 19 inactive GO patients with non-smoking (non-smoker group) were recruited in this prospective study. After detailed ophthalmological examination, vessel densities (VD) of the superficial capillary plexus (SCP), deep capillary plexus (DCP), retinal peripapillary capillary (RPC) and foveal avascular zone (FAZ) area, and acircularity index (AI) of the FAZ were analysed with optical coherence tomography angiography (OCTA) for each eye.

Results

Vessel density in the total peripapillary; superior and inferior sectors of RPC were significantly lower in inactive GO patients with smoking (p < 0.05 for all sectors) compared to control group. Besides, the FAZ AI was significantly higher in smoker and non-smoker inactive GO groups compared to healthy subjects (p = 0.0001, p = 0.0001, respectively). No significant difference was found in the FAZ area, and all SCP, DCP macular measurements between groups (p > 0.05 for all).

Conclusion

OCTA findings of lower peripapillary VD in the smoker group show smoking effect on the optic disc head microvasculature in inactive GO patients. These results could reflect early subclinical optic disc vasculature damage in smoker inactive GO subjects.

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Authors and Affiliations

  1. University of Health Sciences, Ulucanlar Eye Education and Research Hospital, 06250, Altındağ, Ankara, Turkey

    Kubra Serbest Ceylanoglu, Emine Malkoc Sen, Sibel Doguizi & Gozde Hondur

Authors
  1. Kubra Serbest Ceylanoglu
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  2. Emine Malkoc Sen
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  3. Sibel Doguizi
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  4. Gozde Hondur
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Correspondence to Kubra Serbest Ceylanoglu.

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All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Ceylanoglu, K.S., Sen, E.M., Doguizi, S. et al. Smoking effect on peripapillary and macular microvascular structure in inactive Graves’ ophthalmopathy. Int Ophthalmol 41, 3411–3417 (2021). https://doi.org/10.1007/s10792-021-01904-z

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  • DOI: https://doi.org/10.1007/s10792-021-01904-z

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