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Incidence and changing patterns of uveitis in Central Tokyo

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Abstract

Purpose

The patterns of uveitis in Tokyo have recently changed due to advances in examination tools. We aimed to investigate the changes in the patterns of uveitis between 2004–2015 and 2016–2018.

Methods

We retrospectively reviewed the data of 732 patients who visited the Uveitis Clinic at the University of Tokyo Hospital between January 2016 and December 2018. Background characteristics, laboratory results, and imaging findings were analysed. We compared the incidences of uveitis in 2016–2018 and 2004–2015 to identify changes in the patterns.

Results

The most frequent diagnoses were sarcoidosis (8.9%), herpetic iridocyclitis (6.7%), intraocular lymphoma (5.5%), Vogt–Koyanagi–Harada disease (4.8%), unclassified acute anterior uveitis (4.6%), Behçet’s disease (4.5%), bacterial endophthalmitis (2.9%), and Posner-Schlossman syndrome (2.6%). Suspected sarcoidosis (20.9%) was the most common cause of unclassified uveitis. The incidence of intraocular lymphoma was significantly higher in 2016–2018 than in 2004–2015. Between 2004 and 2018, herpetic iridocyclitis, bacterial endophthalmitis, and juvenile chronic iridocyclitis exhibited an increasing trend, and the incidences of Posner-Schlossman syndrome, unclassified acute anterior uveitis, Behçet’s disease, and Vogt–Koyanagi–Harada disease exhibited a decreasing trend.

Conclusion

The changing patterns of uveitis were characterised by increases in the incidence of intraocular lymphoma. This may be attributed to recent advances in examination tools, the changes in the referred patient population, and the aging Japanese population.

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Availability of data and materials

The datasets used and analysed in the current study are available from the corresponding author on reasonable request.

Code availability

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Acknowledgements

The manuscript was edited for English grammar by a native writer at Editage.

Funding

This work was supported, in part, by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (KAKENHI No. 18K09398, No. 19K09986), a Grant-in-Aid for Research on Refractory Diseases of the Health Sciences Research from the Ministry of Health, Labour, and Welfare (#20FC1012), and a Grant-in-Aid for Eisai Japan (2019), Alcon, Novartis Pharma (2019), and Santen Pharmaceutical (2019).

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Authors and Affiliations

  1. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Takafumi Suzuki, Toshikatsu Kaburaki, Rie Tanaka, Shintaro Shirahama, Keiko Komae, Hisae Nakahara, Mitsuko Takamoto & Makoto Aihara

  2. Department of Ophthalmology, Shinseikai Toyama Hospital, Toyama, 939-0243, Japan

    Takafumi Suzuki

  3. Department of Ophthalmology, Jichi Medical University Saitama Medical Center, 1-847 Amanuma, Ohmiya-ku, Saitama, Saitama, 330-8503, Japan

    Toshikatsu Kaburaki

  4. Department of Ophthalmology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan

    Hidetoshi Kawashima

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  1. Takafumi Suzuki
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Contributions

TS was involved in the study design, data collection, analysis of the results, and drafting of the manuscript. TK and SS participated in the study design, data collection, and reviewing and editing of the manuscript. RT, KK, HN, MT, HK, and MA participated in the data collection and reviewing and editing of the manuscript. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Toshikatsu Kaburaki.

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Conflict of interests

The authors declare that they have no competing interests.

Ethical approval

This retrospective study was approved by the research ethics committee of the Graduate School of Medicine and Faculty of Medicine at The University of Tokyo. This study was conducted in compliance with the Declaration of Helsinki and the ethical guidelines for medical and health research involving human subjects.

Consent to participate

We used an opt-out approach, which is a substitute for consent, by informing participants of the purpose and conduct of the study and guaranteeing them the opportunity to be excluded, rather than obtaining direct consent from each patient.

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Suzuki, T., Kaburaki, T., Tanaka, R. et al. Incidence and changing patterns of uveitis in Central Tokyo. Int Ophthalmol 41, 2377–2388 (2021). https://doi.org/10.1007/s10792-021-01791-4

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