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Ultra-widefield fundus fluorescein angiography findings in patients with ankylosing spondylitis experiencing uveitis

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Abstract

Aim

To evaluate ultra-widefield fundus fluorescein angiography (FFA) findings in cases of ankylosing spondylitis (AS)-associated uveitis.

Materials and methods

Forty-five eyes of 23 AS patients followed up with a diagnosis of uveitis were included.

Results

Sixteen (69.6%) men and seven (30.4%) women with a mean age of 46.26 ± 10.87 years were included in the study. Retinal vascular leakage was observed in 19 (42.2%) eyes at FFA, diffuse in six (13.3%) and peripheral in 13 (28.9%) eyes. Active anterior uveitis attack was present in seven (36.8%) eyes with vascular leakage at FFA, while no active uveitis findings were present in 12 (63.15%) eyes. No statistical relation was determined between peripheral and diffuse leakage and active uveitis (p = 0.195). No significant association was also determined between both diffuse and peripheral leakage and visual acuity (p = 0.066).

Conclusion

We observed widespread retinal vascular leakage at UWF angiography in AS patients (in eyes undergoing active uveitis attacks and inactive eyes).

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References

  1. Gouveia EB, Elmann D, Morales MS (2012) Ankylosing spondylitis and uveitis: overview. Rev Bras Reumatol 52:742–756

    Article  Google Scholar 

  2. Zeboulon N, Dougados M, Gossec L (2008) Prevalence and characteristics of uveitis in the spondyloarthropathies: a systematic literature review. Ann Rheum Dis 67:955–959

    Article  CAS  Google Scholar 

  3. Sampaio-Barros PD, Conde RA, Bonfiglioli R, Bertolo MB, Samara AM (2006) Characterization and outcome of uveitis in 350 patients with spondyloarthropathies. Rheumatol Int 26:1143–1146

    Article  Google Scholar 

  4. Lee JH, Choi M, Rim THT, Lee SC, Lee SC (2019) Clinical characteristics and prognostic factors in ankylosing spondylitis associated uveitis. Ocul Immunol Inflamm 27(1):64–69

    Article  Google Scholar 

  5. Pathanapitoon K, Dodds EM, Cunningham ET, Rothova A (2017) Clinical spectrum of HLA-B27-associated ocular inflammation. Ocul Immunol Inflamm 25(4):569–576

    Article  CAS  Google Scholar 

  6. Rodriguez A, Akova YA, Pedroza-Seres M, Foster CS (1994) Posterior segment ocular manifestations in patients with HLA-B27-associated uveitis. Ophthalmology 101:1267–1274

    Article  CAS  Google Scholar 

  7. Chi Y, Guo C, Peng Y, Qiao L, Yang L (2015) A prospective, observational study on the application of ultra-wide-field angiography in the evaluation and management of patients with anterior uveitis. Plos One 10(3):e0122749

    Article  Google Scholar 

  8. Yang P, Wan W, Du L, Zhou Q, Qi J, Liang L, Wang C, Wu L, Kijlstra A (2018) Clinical features of HLA-B27-positive acute anterior uveitis with or without ankylosing spondylitis in a Chinese Cohort. Br J Ophthalmol 102:215–219

    Article  Google Scholar 

  9. Jabs DA, Nussenblatt RB, Rosenbaum JT (2005) Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 140(3):509–516

    Article  Google Scholar 

  10. Laovirojjanakul W, Acharya N, Gonzales JA (2019) Ultra-widefield fluorescein angiography in intermediate uveitis. Ocul Immunol Inflamm 27(3):356–361

    Article  Google Scholar 

  11. Leder HA, Campbell JP, Sepah YJ, Gan T, Dunn JP, Hatef E, Cho B, Ibrahim M, Bittencourt M, Channa R et al (2013) Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis. J Ophthalmic Indlamm Infect 3(1):1–6. https://doi.org/10.1186/1869-5760-3-30

    Article  Google Scholar 

  12. Basarir B, Celik U, Altan C, Celik NM (2018) Choroidal thickness changes determined by EDI-OCT on acute anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. Int Ophthalmol 38:307–312

    PubMed  Google Scholar 

  13. Yan H, Li J, Zhang J, Yang L (2017) Retinal and choroidal thickness in patients with uveitis. Ocul Immunol Inflamm 25(2):202–209

    Article  Google Scholar 

  14. Kola M, Kalkışım A, Karkucak M, Turk A, Capkın E, Can I, Serdar ÖF, Mollamehmetoglu S, Ayar A (2014) Evaluation of choroidal thickness in ankylosing spondylitis using optical coherence tomography. Ocul Immunol Inflamm 22(6):434–438

    Article  Google Scholar 

  15. Gunal EK, Sarvan FO, Kamali S, Gul A, Inanc M, Carın M, Konice M, Aral O, Ocal L (2008) Low frequency of HLA-B27 in ankylosing spondylitis patients from Turkey. Joint Bone Spine 75(3):299–302

    Article  Google Scholar 

  16. Akkoç N, Yarkan H, Kenar G, Khan MA (2017) Ankylosing spondylitis: HLA-B*27-positive versus HLA-B*27-negative disease. Curr Rheumatol Rep 19:26

    Article  Google Scholar 

  17. Lin H, Gong YZ (2017) Association of HLA-B27 with ankylosing spondylitis and clinical features of the HLA-B27-associated ankylosing spondylitis: a meta-analysis. Rheumatol Int 37:1267–1280

    Article  CAS  Google Scholar 

  18. Chung HY, Machado P, van der Heijde D, D’Agostino MA, Dougados M (2011) HLA-B27 positive patients differ from HLA-B27 Negative patients in clinical presentation and imaging: results from the DESIR cohort of patients with recent onset axial spondyloarthritis. Ann Rheum Dis 70(11):1930–1936

    Article  Google Scholar 

  19. Kim M, Won JY, Choi SY, Ju JH, Park YH (2016) Anti-TNF alpha treatment for HLA-B27-positive ankylosing spondylitis related uveitis. Am J Ophthalmol 170:32–40

    Article  CAS  Google Scholar 

  20. Kım M, Won JY, Choı SY, Ju JH, Park YH (2016) Anti-TNF treatment for HLA-B27-positive ankylosing spondylitis-related uveitis. Am J Ophthalmol 170:32–40

    Article  Google Scholar 

  21. Lie E, Lindström U, Sandström SZ, Olsen I, Forsblad-d’Elia H, Askling J, Kapetanovic M, Kristensen LE, Jacobsson LTH (2017) Tumour necrosis factor inhibitor treatment and occurrence of anterior uveitis in ankylosing spondylitis: results from the Swedish biologics register. Ann Rheum Dis 76:1515–1521

    Article  CAS  Google Scholar 

  22. Shah A, Abbey AM, Yonekawa Y, Khandan S, Wolfe JD, Trese M, Williams GA, Capone A (2016) Widefield fluorescein angiography in patients without peripheral disease a study of normal peripheral findings. Retina 36:1087–1092

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey

    Dilek Uzlu, Hidayet Erdöl & Nurettin Akyol

  2. The State Hospital of Bayburt, Bayburt, Turkey

    Büşra Köse

Authors
  1. Dilek Uzlu
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  2. Büşra Köse
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  3. Hidayet Erdöl
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  4. Nurettin Akyol
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Correspondence to Dilek Uzlu.

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The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Approval of the institutional review board (IRB). The study was approved by Karadeniz Technical University, Faculty of Medicine.

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Uzlu, D., Köse, B., Erdöl, H. et al. Ultra-widefield fundus fluorescein angiography findings in patients with ankylosing spondylitis experiencing uveitis. Int Ophthalmol 40, 2627–2634 (2020). https://doi.org/10.1007/s10792-020-01443-z

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  • DOI: https://doi.org/10.1007/s10792-020-01443-z

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