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Recent advances in the diagnosis and treatment of Coats’ disease

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Abstract

Purpose

To review and summarize the recent progress in the diagnosis and treatment of Coats’ disease.

Methods

Literature was collected from Web of Science, Medline and Pubmed, through searching of these keywords: “Coats’ disease”, “diagnosis” and “treatment”.

Results

Coats’ disease is characterized by idiopathic leaky retinal vascular telangiectasia and microvascular abnormalities often accompanied by intraretinal or subretinal exudation and retinal detachment. Neovascular glaucoma and phthisis bulbi often occur in advanced cases. Coats’ disease has significant diversity in terms of its clinical presentation and morphology. Anti-VEGF therapy combined with laser photocoagulation for early Coats’ disease and anti-VEGF therapy combined with minimally invasive vitrectomy for advanced Coats’ disease can achieve good efficacy.

Conclusion

Early diagnosis and timely treatment based on clinical stage are critical to retaining the patient’s visual function. Patients should be aware that close long-term follow-up is necessary.

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Acknowledgements

This work was supported by all members of the Central Laboratory of the Second Hospital at Jilin University. The authors alone are responsible for the content and writing of the paper.

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  1. Department of Ophthalmology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, Jilin, China

    Xinyue Yang, Chenguang Wang & Guanfang Su

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  1. Xinyue Yang
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Correspondence to Guanfang Su.

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Yang, X., Wang, C. & Su, G. Recent advances in the diagnosis and treatment of Coats’ disease. Int Ophthalmol 39, 957–970 (2019). https://doi.org/10.1007/s10792-019-01095-8

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