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Evaluation of optic disc, retinal nerve fiber and macular ganglion cell layers in pediatric diabetes

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Abstract

Purpose

Our aim was to compare optic disc parameters, retinal nerve fiber (RNFL) and macular ganglion cell layers between children and adolescents with diabetes mellitus (type 1) and healthy controls.

Methods

Sixty-three eyes of 63 pediatric diabetic patients without diabetic retinopathy and 44 eyes of 44 healthy controls were included in this cross-sectional and comparative study. Diabetic and control groups were similar in the aspect of age, gender and refractive error. Measurements of optic disc parameters (i.e., rim area, disc area, cup-to-disc ratio, cup volume), thickness of RNFL and macular ganglion cell—inner plexiform layers (GCL + IPL) were taken with the spectral domain optical coherence tomography.

Results

There were not statistically significant differences between the diabetic patients and healthy controls in terms of intraocular pressure (p = 0.14), retinal nerve fiber layer thickness (p = 0.61), rim area (p = 0.92), disc area (p = 0.10), vertical cup-to-disc ratio (p = 0.16), cup volume (p = 0.13), and average macular GCL + IPL thickness (p = 0.43). On the other hand, binocular RNFL thickness symmetry percentage was statistically significantly different in the diabetic and control groups (p = 0.01).

Conclusion

Diabetic children and adolescents without diabetic retinopathy have more binocular RNFL thickness asymmetry compared to healthy controls.

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Authors and Affiliations

  1. Denizli State Hospital, Eye Clinic, Denizli, Turkey

    Evre Pekel

  2. Denizli State Hospital, Pediatric Endocrinology, Denizli, Turkey

    Selda Ayça Altıncık

  3. Ophthalmology Department, Pamukkale University, 20070, Denizli, Turkey

    Gökhan Pekel

Authors
  1. Evre Pekel
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  2. Selda Ayça Altıncık
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  3. Gökhan Pekel
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Correspondence to Gökhan Pekel.

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Conflict of interest

Evre Pekel declares that she has no conflict of interest. Selda Ayça Altıncık declares that she has no conflict of interest. Gökhan Pekel declares that he has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Pekel, E., Altıncık, S.A. & Pekel, G. Evaluation of optic disc, retinal nerve fiber and macular ganglion cell layers in pediatric diabetes. Int Ophthalmol 38, 1955–1961 (2018). https://doi.org/10.1007/s10792-017-0683-3

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  • DOI: https://doi.org/10.1007/s10792-017-0683-3

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