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Brimonidine–timolol versus brinzolamide–timolol for treatment of elevated intraocular pressure after phacoemulsification surgery

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Abstract

Purpose

To compare the efficacy of the fixed combination of brimonidine–timolol (FCBT) and the fixed combination of brinzolamide–timolol (FCBZT) treatments for elevated intraocular pressure (IOP) after phacoemulsification cataract surgery.

Methods

A randomised, prospective, double-blinded study was conducted on 277 eyes of 257 patients who underwent phacoemulsification cataract surgery. Patients were divided into three groups based on the medication administered after cataract surgery as follows: FCBT, FCBZT and a control group where no antiglaucoma medications were used. IOP was recorded at preoperative and postoperative hours 6 and 24 and days 3 and 5.

Results

No statistical differences were observed among the groups regarding age, sex and baseline IOP levels (p > 0.05). Mean IOP levels were significantly lower in the treatment groups than in the control group at postoperative hours 6 and 24 and days 3 and 5 (p < 0.001). Administration of one drop of FCBT or FCBZT demonstrated similar effects on preventing IOP spikes within 24 h of phacoemulsification cataract surgery. FCBZT more effectively lowered IOP than FCBT at days 3 and 5 (p < 0.05).

Conclusions

We demonstrate that the postoperative administration of FCBT or FCBZT is effective in lowering IOP after phacoemulsification cataract surgery; FCBZT more effectively lowered IOP than FCBT at postoperative days 3 and 5.

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Authors and Affiliations

  1. Diyarbakır Research and Education Hospital, Diyarbakir, Turkey

    Selahattin Balsak & M. Fuat Alakus

  2. Department of Anesthesiology, Diyarbakır Selahaddini Eyyübi State Hospital, 21100, Diyarbakir, Turkey

    Ayhan Kaydu

  3. Diyarbakir Bismil State Hospital, Diyarbakir, Turkey

    Seyfettin Erdem

  4. Dicle University Medical Faculty, Diyarbakir, Turkey

    Zeynep Gursel Ozkurt

Authors
  1. Selahattin Balsak
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  2. Ayhan Kaydu
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  3. Seyfettin Erdem
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  4. M. Fuat Alakus
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  5. Zeynep Gursel Ozkurt
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Correspondence to Ayhan Kaydu.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organisation or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership or other equity interest; and expert testimony or patent–licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Balsak, S., Kaydu, A., Erdem, S. et al. Brimonidine–timolol versus brinzolamide–timolol for treatment of elevated intraocular pressure after phacoemulsification surgery. Int Ophthalmol 38, 1583–1589 (2018). https://doi.org/10.1007/s10792-017-0626-z

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  • DOI: https://doi.org/10.1007/s10792-017-0626-z

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