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Fast Terahertz Spectroscopic Holographic Assessment of Optical Properties of Diabetic Blood Plasma

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Abstract

A new method for diagnosis of diabetes mellitus is proposed, which uses for measurement a lyophilized blood plasma sample prepared in the form of a pellet. The paper develops a methodology for fast spectroscopic measurements of such pellets with terahertz pulse time-domain holography. For that reason, blood plasma pellets were experimentally measured by terahertz time-domain spectroscopy system in transmission mode and its characteristics were obtained to be then used in numerical simulation of pulse terahertz hologram formation and extraction of its optical properties. Thus, a demonstration of the proof-of-concept was given for the techniques of pellet inspection, which contains information about the presence of glycated proteins, reflecting a diabetic pathology.

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Funding

The reported study was funded by RFBR-CNRS according to the research project 18-51-16002 and RFBR 17-00-00275 (17-00-00272), and by the Government of the Russian Federation (Grant 08-08). N.S.B. received support from the Russian Ministry of Education and Science (project within the state mission for institutions of higher education, agreement 3.1893.2017/4.6). M.S.K. received support RFBR project 18-32-20215/18.

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Authors and Affiliations

  1. Institute of Photonics and Optical Information Technologies, ITMO University, 3 Kadetskaya str., 199004, Saint-Petersburg, Russia

    Maksim S. Kulya, Evgeniy L. Odlyanitskiy, Polina G. Gavrilova, Nikolay S. Balbekin, Nikolay V. Petrov & Olga A. Smolyanskaya

  2. IMS Laboratory UMR CNRS 5218, Bordeaux University, 351 Cours de la Liberation, 33045, Talence, France

    Quentin Cassar, Patrick Mounaix & Jean-Paul Guillet

  3. Ioffe Institute, 26 Politekhnicheskaya str., 194021, Saint-Petersburg, Russia

    Ilia A. Mustafin & Valery N. Trukhin

  4. Almazov National Medical Research Centre, 2 Akkuratova str., 197341, Saint-Petersburg, Russia

    Dmitry V. Korolev & Yulia A. Kononova

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  1. Maksim S. Kulya
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  2. Evgeniy L. Odlyanitskiy
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  3. Quentin Cassar
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  6. Polina G. Gavrilova
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  8. Yulia A. Kononova
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  9. Nikolay S. Balbekin
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Correspondence to Olga A. Smolyanskaya.

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Kulya, M.S., Odlyanitskiy, E.L., Cassar, Q. et al. Fast Terahertz Spectroscopic Holographic Assessment of Optical Properties of Diabetic Blood Plasma. J Infrared Milli Terahz Waves 41, 1041–1056 (2020). https://doi.org/10.1007/s10762-020-00728-9

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