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Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

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Abstract

Campomanesia xanthocarpa (Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2′,6′-dihydroxy-3′-methyl-4′-metoxychalcone and 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone were identified for the first time in leaves of the C. xanthocarpa. These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.

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Authors and Affiliations

  1. Program in Natural Resources, State University of Mato Grosso do Sul, Dourados, MS, Brazil

    Élica Renata Soares da Silva & Cláudia Andréa Lima Cardoso

  2. Universidade Estadual de Mato Grosso do Sul, CEP 79804-970, C.P. 351, Dourados, MS, Brazil

    Élica Renata Soares da Silva, Gustavo Ruivo Salmazzo & Cláudia Andréa Lima Cardoso

  3. College of Health Science, Federal University of Grande Dourados, Dourados, MS, Brazil

    Jucicléia da Silva Arrigo & Candida Aparecida Leite Kassuya

  4. School of Medicine “Dr. Hélio Mandetta” (FAMED), Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil

    Rodrigo Juliano Oliveira

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  1. Élica Renata Soares da Silva
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Correspondence to Élica Renata Soares da Silva or Cláudia Andréa Lima Cardoso.

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Ethical Approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted. According to the Ethics Committee on Animal Use the Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil (CEUA/UFGD). This work was found to comply with the ethical concepts required by the National Council for Animal Experiments Control (CONCEA), with current legislation and other provisions of the ethics investigations that directly involve the use of animals and was approved on April 9, 2014, through the protocol number 028/2014.

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da Silva, É.R.S., Salmazzo, G.R., da Silva Arrigo, J. et al. Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg. Inflammation 39, 1462–1468 (2016). https://doi.org/10.1007/s10753-016-0378-3

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