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GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis

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An Erratum to this article was published on 20 November 2007

Abstract

The neurotransmitter GABA exerts a strong negative influence on the production of adult-born olfactory bulb interneurons via tightly regulated, non-synaptic GABAergic signaling. After discussing some findings on GABAergic signaling in the neurogenic subventricular zone (SVZ), we provide data suggesting ambient GABA clearance via two GABA transporter subtypes and further support for a non-vesicular mechanism of GABA release from neuroblasts. While GABA works in cooperation with the neurotransmitter glutamate during embryonic cortical development, the role of glutamate in adult forebrain neurogenesis remains obscure. Only one of the eight metabotropic glutamate receptors (mGluRs), mGluR5, has been reported to tonically increase the number of proliferative SVZ cells in vivo, suggesting a local source of glutamate in the SVZ. We show here that glutamate antibodies strongly label subventricular zone (SVZ) astrocytes, some of which are stem cells. We also show that some SVZ neuroblasts express one of the ionotropic glutamate receptors, AMPA/kainate receptors, earlier than previously thought. Collectively, these findings suggest that neuroblast-to-astrocyte GABAergic signaling may cooperate with astrocyte-to-neuroblast glutamatergic signaling to provide strong homeostatic control on the production of adult-born olfactory bulb interneurons.

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Acknowledgment

This work was supported by a grant from the National Institute of Health R01 NS048256 and DC007681 (A.B.) and NSF graduate Research Fellowship (B.L.).

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  1. Departments of Neurosurgery, and Cellular & Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, FMB 422, New Haven, CT, 06520-8082, USA

    Jean-Claude Platel, Benjamin Lacar & Angélique Bordey

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  1. Jean-Claude Platel
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  2. Benjamin Lacar
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  3. Angélique Bordey
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Correspondence to Angélique Bordey.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s10735-007-9153-y

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Platel, JC., Lacar, B. & Bordey, A. GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis. J Mol Hist 38, 303–311 (2007). https://doi.org/10.1007/s10735-007-9103-8

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