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Partnering in Oncogenetic Research – The INHERIT BRCAs Experience: Opportunities and Challenges

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Abstract

Today it is common to conduct research in collaboration with colleagues from different disciplines and institutions. The INterdisciplinary HEalth Research International Team on BReast CAncer susceptibility (INHERIT BRCAs), involves Canadian and international experts from diverse fields working with health service providers, patients and collaborators from the World Health Organization and other European networks. Evidence-based information and knowledge transfer drive our efforts to advance genomic research to understand the genetic basis of cancer susceptibility and treatment response. Several goals reveal the interdisciplinary team approach: (a) to estimate the prevalence and penetrance of BRCA1 and BRCA2 mutations and their deleterious impact upon different populations; (b) to pinpoint novel breast cancer susceptibility loci; (c) to assess the efficacy of clinical interventions; (d) to address changes in quality of life and health-related behaviour from the decision to undergo genetics testing and during follow-up; (e) to evaluate legal, social and ethical implications; and, finally; (f) to promote professional and public education by facilitating the transfer of research findings to clinical practice and informing policy makers. The lessons learned by the INHERIT research team and future challenges are presented.

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Authors and Affiliations

  1. Centre de Recherche en Droit Public, Faculty of Law, University of Montreal, Montreal, Canada

    Denise Avard, Lucie M. Bucci, Béatrice Godard & Bartha Maria Knoppers

  2. Molecular Diagnostic Laboratory, Alberta Children’s Hospital, Departments of Medical Genetics and Pathology, Faculty of Medicine, University of Calgary, Calgary, Canada

    Peter Bridge

  3. Clinique des Maladies du Sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec, Canada

    Jocelyne Chiquette

  4. Unité de Recherche en Santé des Populations, CHA Research Center, Hôpital du Saint-Sacrement, Faculty of Pharmacy, Laval University, Québec, Canada

    Michel Dorval

  5. Cancer Genomics Laboratory, CHUL Research Centre, CHUQ, Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Québec, Canada

    Francine Durocher & Jacques Simard

  6. CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge, UK

    Doug Easton

  7. Faculty of Medicine, University of Montreal, Montreal, Canada

    Béatrice Godard

  8. Genetic Epidemiology Unit, International Agency for Research on Cancer, World Health Organization, Lyon, France

    David Goldgar

  9. Canada Research Chair in Law and Medicine, Canada

    Bartha Maria Knoppers

  10. Clinical Genetics Division, Department of Paediatrics and Medicine, CHUL, CHUQ, Faculty of Medicine, Laval University, Québec, Canada

    Rachel Laframboise

  11. Department of Haemato-Oncology, Hôpital du Sacré-Coeur de Montréal, Faculty of Medicine, University of Montreal, Montreal, Canada

    Bernard Lespérance

  12. Gynaecology Service, Gynaecologic Oncology Division, Hôtel-Dieu de Québec, CHUQ, Department of Obstetrics and Gynaecology, Faculty of Medicine, Laval University, Québec, Canada

    Marie Plante

  13. Unit of Genetic Cancer Susceptibility, International Agency for Research on Cancer, World Health Organization, Lyon, France

    Sean V. Tavtigian

  14. Department of Human Sciences, Interdisciplinary Research Group in Genetic Demography and Epidemiology (GRIG), Université du Québec à Chicoutimi, Chicoutimi, Canada

    Hélène Vézina

  15. Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Canada

    Brenda Wilson

  16. Canada Research Chair in Oncogenetics, Canada

    Jacques Simard

  17. Centre de Recherche en Droit Public, Faculty of Law, University of Montreal, 3101 Chemin de la Tour, Office 8447, Montreal, Canada, H3T IJ7

    Denise Avard

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  1. Denise Avard
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INHERIT BRCAs

Corresponding author

Correspondence to Denise Avard.

Additional information

* The Interdisciplinary Health Research International Team on Breast Cancer Susceptibility (INHERIT BRCAs) is an international team of researchers with a major interest in inherited breast cancer. The team is funded by the Canadian Institutes of Health Research. Other members and collaborators of INHERIT BRCAs involved in this study are listed in Appendix A.

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Avard, D., Bridge, P., Bucci, L.M. et al. Partnering in Oncogenetic Research – The INHERIT BRCAs Experience: Opportunities and Challenges. Familial Cancer 5, 3–13 (2006). https://doi.org/10.1007/s10689-005-2570-8

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