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Cyclodextrin polymers decorated with RGD peptide as delivery systems for targeted anti-cancer chemotherapy

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Summary

Polymeric cyclodextrin–based nanoparticles are currently undergoing clinical trials as nanotherapeutics. Using a non-covalent approach, we decorated two cross-linked cyclodextrin polymers of different molecular weights with an RGD peptide derivative to construct a novel carrier for the targeted delivery of doxorubicin. RGD is the binding sequence for the integrin receptor family that is highly expressed in tumour tissues. The assembled host–guest systems were investigated using NMR and DLS techniques. We found that, in comparison with free doxorubicin or the binary complex doxorubicin/cyclodextrin polymer, the RGD units decorating the cyclodextrin-based nanosystems improved the selectivity and cytotoxicity of the complexed doxorubicin towards cultured human tumour cell lines. Our results suggest that the nanocarriers under study may contribute to the development of new platforms for cancer therapy.

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Acknowledgments

The authors are grateful for support from Università degli Studi di Catania (Piano della Ricerca di Ateneo 2016-2018) and the Italian Ministero dell’Università e della Ricerca. Training grant PO FSE 2014-2020 (Tosto R.) is also gratefully acknowledged.

Funding

This study was funded by Università degli Studi di Catania (Piano della Ricerca di Ateneo 2016-2018) and PO FSE 2014-2020 (MIUR).

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Authors and Affiliations

  1. IRCCS Ospedale Policlinico San Martino, U.O.C. Bioterapie, L.go R. Benzi 10, 16132, Genoa, Italy

    Maurizio Viale & Irena Maric

  2. CNR Istituto di Biostrutture e Bioimmagini, Sede di Catania, Via Paolo Gaifami 18, 95126, Catania, Italy

    Rita Tosto & Giuseppe Pappalardo

  3. Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125, Catania, Italy

    Valentina Giglio, Valentina Oliveri & Graziella Vecchio

  4. Dipartimento di Scienze Biomediche ed Oncologia Umana, Università degli Studi di Bari Aldo Moro, Piazza G. Cesare 11, 70124, Bari, Italy

    Maria Addolorata Mariggiò

Authors
  1. Maurizio Viale
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  2. Rita Tosto
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  3. Valentina Giglio
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  4. Giuseppe Pappalardo
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  5. Valentina Oliveri
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  7. Maria Addolorata Mariggiò
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  8. Graziella Vecchio
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Correspondence to Giuseppe Pappalardo or Graziella Vecchio.

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Viale, M., Tosto, R., Giglio, V. et al. Cyclodextrin polymers decorated with RGD peptide as delivery systems for targeted anti-cancer chemotherapy. Invest New Drugs 37, 771–778 (2019). https://doi.org/10.1007/s10637-018-0711-9

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  • DOI: https://doi.org/10.1007/s10637-018-0711-9

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