Abstract
Background and Aims
Boerhaave’s syndrome, involving esophagus rupture, is considered a pathological response to vomiting that may occur just before perforation. However, the mechanism of vomiting and occurrence of this disease have not been clearly demonstrated.
Methods
We identified patients with esophageal perforation between 1995 and 2017 and reviewed endoscopic findings at retching during upper gastrointestinal endoscopy. Finally, we proposed a theory for the underlying pathological mechanism.
Results
We retrospectively investigated 10 patients with esophageal perforation between 1995 and 2017. All patients presented after vomiting associated with large volumes of food and alcohol intake. Nine were treated by primary closure of the perforation and drainage of the thoracic cavity, and one was conservatively treated. In all cases, the perforations were longitudinal tears (1–4 cm) and located in the left of the esophagus, just above the gastric cardia.
Conclusions
We hypothesize that vomiting occurred by retrograde propagation of gastrointestinal motor contraction from the jejunum to the gastric antrum, followed by prolapse of the gastric fornix mucosal into the esophagus. Subsequent esophageal perforation probably resulted from excessive prolapse due to strong contraction and destruction of the muscularis mucosa of the left side of abdominal esophagus, with longitudinal stretching of the whole left esophageal wall due to traction. We also propose that Boerhaave’s syndrome is defined as “post-emetic esophageal perforation” to ensure broader recognition and more expedient diagnosis and treatment. Remaining conditions without any definite causes may be labeled “idiopathic” or “spontaneous” rupture of the esophagus.
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Acknowledgments
We thank Dr. Soichiro Maekawa MD. PhD, Ms Sayaka Okada, and Kayoko Takahashi for their skillful assistance.
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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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Kuwano, H., Yokobori, T., Kumakura, Y. et al. Pathophysiology of Vomiting and Esophageal Perforation in Boerhaave’s Syndrome. Dig Dis Sci 65, 3253–3259 (2020). https://doi.org/10.1007/s10620-019-06028-0
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DOI: https://doi.org/10.1007/s10620-019-06028-0