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Survival of Colorectal Cancer in Patients With or Without Inflammatory Bowel Disease: A Meta-Analysis

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Abstract

Background

Patients with inflammatory bowel disease (IBD) are at increased risk of colorectal cancer (CRC), but little is known about the influence of IBD on CRC prognosis.

Aims

The aim of this study was to perform a meta-analysis to compare survival in CRC patients with IBD (IBD-CRC) and without IBD.

Methods

An electronic search was conducted via PubMed, Embase, and the Cochrane Library to identify eligible trials until July 2015. We pooled the hazard ratios (HRs) and their 95 % confidence intervals (CIs) to quantitatively assess the survival of CRC in patients with or without IBD. In addition, clinicopathological parameters of IBD-CRC versus non-IBD CRC were evaluated.

Results

Twelve studies containing a total of 3472 IBD-CRC patients were eligible according to our selection criteria. Our analysis indicated that CRC patients with IBD had shorter overall survival than those without IBD (HR 1.24, 95 % CI 1.19–1.29). IBD-CRC showed a propensity to develop in proximal colon [odds ratio (OR) 2.52, 95 % CI 1.35–4.72] and correlated with worse differentiation of tumor (OR 1.59, 95 % CI 1.26–1.99) compared to non-IBD CRC. Meta-regression analysis showed that sample size (P = 0.002) could explain 99.01 % inter-study heterogeneity.

Conclusion

This meta-analysis found poorer overall survival in CRC patients with IBD than CRC patients without IBD, and further prospective research to confirm these findings is warranted.

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Acknowledgments

This research was supported by Shanghai Natural Science Foundation (124119a0900).

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    Authors and Affiliations

    1. Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China

      Baochi Ou, Jingkun Zhao, Shaopei Guan & Aiguo Lu

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    1. Baochi Ou
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    2. Jingkun Zhao
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    3. Shaopei Guan
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    4. Aiguo Lu
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    Correspondence to Aiguo Lu.

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    Baochi Ou and Jingkun Zhao have contributed equally to this work.

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    Ou, B., Zhao, J., Guan, S. et al. Survival of Colorectal Cancer in Patients With or Without Inflammatory Bowel Disease: A Meta-Analysis. Dig Dis Sci 61, 881–889 (2016). https://doi.org/10.1007/s10620-015-3940-1

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    • DOI: https://doi.org/10.1007/s10620-015-3940-1

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