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Morphological Characteristics of Early Gastric Neoplasms Detected After Helicobacter pylori Eradication

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Abstract

Background

Previous morphological studies indicated that the eradication of Helicobacter pylori (H. pylori) made gastric neoplasms endoscopically indistinct through the flattening and covering of tumors with a non-neoplastic epithelium (NE).

Aim

To validate these alterations.

Methods

We reviewed and compared the endoscopic and histological findings of early gastric carcinomas and high-grade dysplasias resected endoscopically from H. pylori-infected and H. pylori-eradicated patients. The extent of NE covering a tumor was expressed as the histological length ratio of NE to the tumor. Tumor morphology was compared before and after therapies in patients who received H. pylori eradication treatments during the period from tumor discovery to endoscopic resection.

Results

NE-covered ratios were higher in the 59 tumors detected after the eradication of H. pylori than in the 152 tumors detected during the infection (median 8 vs. 0 %, respectively), whereas the frequency at which an elevated morphology and whitish discoloration of a tumor were observed was less (14 vs. 56 %, and 14 vs. 43 %, respectively). These were also independent characteristics for tumors detected after the eradication of H. pylori. Two elevated tumors showing whitish discoloration out of 16 tumors became endoscopically indistinct following H. pylori eradication treatments through the flattening of tumors and muting of the discoloration.

Conclusion

The eradication of H. pylori promoted covering with NE, the flattening of tumors, and muting of the whitish discoloration, which may make a subset of tumors, potentially including whitish elevated neoplasms, indistinct.

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Acknowledgments

The authors thank Ms. Mayumi Yamada for her excellent assistance.

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Authors and Affiliations

  1. Department of Intestinal Inflammation Research, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Kazutoshi Hori & Shiro Nakamura

  2. Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Jiro Watari, Takahisa Yamasaki, Takashi Kondo, Fumihiko Toyoshima, Jun Sakurai, Hisatomo Ikehara, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui & Hiroto Miwa

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  1. Kazutoshi Hori
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  2. Jiro Watari
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  3. Takahisa Yamasaki
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  4. Takashi Kondo
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  5. Fumihiko Toyoshima
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  6. Jun Sakurai
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  11. Shiro Nakamura
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  12. Hiroto Miwa
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Correspondence to Kazutoshi Hori.

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Hori, K., Watari, J., Yamasaki, T. et al. Morphological Characteristics of Early Gastric Neoplasms Detected After Helicobacter pylori Eradication. Dig Dis Sci 61, 1641–1651 (2016). https://doi.org/10.1007/s10620-015-3887-2

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  • DOI: https://doi.org/10.1007/s10620-015-3887-2

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