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Peripheral Arthritis in the Course of Inflammatory Bowel Diseases

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Abstract

Background

Musculoskeletal disorders are well-defined extra-intestinal manifestations of inflammatory bowel diseases (IBD). There is little data regarding the frequencies of IBD and extra-intestinal manifestations from Central and East Europe and Middle Eastern countries.

Aims

To determine the prevalence of peripheral arthritis in IBD and to document the relationship to other extra-intestinal manifestations.

Methods

Enrolled in the study were 357 patients who were diagnosed with IBD from December 2002 through January 2008. All of the patients underwent a detailed whole-body examination by a gastroenterologist and rheumatologist.

Results

IBD-related peripheral arthritis (IBDPA) was found in 66 (18.5%) of the 357 patients (28.3% Crohn’s disease, 13.5% ulcerative colitis; p = 0.001 χ = 11.62). IBDPA was more frequent in female patients (60.6 vs. 39.4%, p = 0.000, χ = 11.12). In eight (12.1%) cases, IBDPA occurred before the onset of IBD. Acute self-limiting episodes, recurrences of the attacks, and persistent symptoms of arthritis were present in 40 (60.6%), 26 (39.3%), and 29 (45.7%) patients, respectively. Arthritis was symmetrical in 33 (50%) cases. Knees (65.2%) and ankles (62.1%) were the most commonly affected joints. Erythema nodosum and pyoderma gangrenosum were more common among patients with IBDPA than patients without it (p = 0.001, χ = 10.49, and p = 0.000 χ = 25.77, respectively).

Conclusions

IBDPA is a frequent extra-intestinal complication of IBD. Those of female gender and the presence of Crohn’s disease, erythema nodosum and pyoderma gangrenosum have a higher risk to develop IBDPA.

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Authors and Affiliations

  1. Department of Gastroenterology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey

    İlhami Yüksel, Ömer Başar & Seyfettin Köklü

  2. Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey

    Hilmi Ataseven, İbrahim Ertuğrul, Aysel Ülker, Ülkü Dağlı & Nurgül Şaşmaz

  3. Kızlarpınarı Caddesi, No: 278/9, Keçiören, Ankara, Türkiye

    İlhami Yüksel

Authors
  1. İlhami Yüksel
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  2. Hilmi Ataseven
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  3. Ömer Başar
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  4. Seyfettin Köklü
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  5. İbrahim Ertuğrul
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  6. Aysel Ülker
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  7. Ülkü Dağlı
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  8. Nurgül Şaşmaz
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Correspondence to İlhami Yüksel.

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Yüksel, İ., Ataseven, H., Başar, Ö. et al. Peripheral Arthritis in the Course of Inflammatory Bowel Diseases. Dig Dis Sci 56, 183–187 (2011). https://doi.org/10.1007/s10620-010-1260-z

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  • DOI: https://doi.org/10.1007/s10620-010-1260-z

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